We have collected information about Targeted Sirna Delivery for you. Follow the links to find out details on Targeted Sirna Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559924/
Jun 25, 2006 · Abstract Therapeutic application of siRNA requires delivery to the correct intracellular location, to interact with the RNAi machinery within the target cell, within the target tissue responsible for the pathology. Each of these levels of targeting poses a significant barrier.Author: Sabrina Oliveira, Gert Storm, Raymond M. Schiffelers
https://www.nature.com/articles/d42859-019-00086-0
Nov 14, 2019 · The major achievement of this work was the proof‑of‑principle demonstration of targeted siRNA delivery in vivo. A similar approach, published a …Author: Christian Schnell
https://engeneic.com/edv-technology/targeted-sirna-delivery/
Targeted siRNA delivery EDVs Combat Drug Resistant Tumors using siRNAs Multi-drug resistance is the biggest threat to long-term survival of cancer patients. Despite treatment, some tumor cells survive chemotherapy and become resistant to the drugs, causing follow-up treatments to fail.
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.201600057
Apr 24, 2016 · In summary, a TfR‐targeted siRNA delivery system was developed based on the T‐shaped lipo‐oligomer 454 complexed with siRNA molecules into core nanoparticles, which were subsequently decorated with PEG‐linked Tf as an 80 kDa large serum protein targeting ligand for surface shielding and cellular uptake, and INF7 as small pH‐triggered peptide for endolysosomal escape.Author: Wei Zhang, Katharina Müller, Eva Kessel, Eva Kessel, Sören Reinhard, Dongsheng He, Dongsheng He, Phi...
https://www.sciencedirect.com/science/article/pii/B9780123942951000044
Targeted siRNA Delivery. Targeted siRNA delivery systems for cancer are a promising new class of experimental therapeutics with the potential to revolutionize medicine with their increased efficiency and relatively low toxicity compared to conventional drugs.Author: Maneesh Gujrati, Zheng-Rong Lu
https://www.nature.com/articles/s41551-018-0214-1
Self-assembled ribonucleoprotein octamers bearing an endosomolytic peptide and a siRNA–targeting-ligand conjugate facilitate endosomal destabilization and targeted delivery, achieving efficient ...Author: Wanyi Tai, Junwei Li, Eva Corey, Xiaohu Gao
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