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https://pubs.acs.org/doi/abs/10.1021/bc060367e
Jul 14, 2007 · We have applied these principles to the delivery of small interfering RNA (siRNA) therapeutics, where systemic delivery is hampered by rapid excretion and nontargeted tissue distribution. Using a PEGlyated quantum dot (QD) core as a scaffold, siRNA and tumor-homing peptides (F3) were conjugated to functional groups on the particle's surface.Author: Austin M. Derfus, Alice A. Chen, Dal-Hee Min, Erkki Ruoslahti, Sangeeta N. Bhatia
https://www.researchgate.net/publication/6207069_Targeted_Quantum_Dot_Conjugates_for_siRNA_Delivery
Targeted delivery of siRNA to undruggable KRAS mutated non-small cell lung cancer cells would sensitize the cells to TKI drugs and offers an efficient therapy for treating cancer; however ...
http://web.ics.purdue.edu/~jfleary/nanomedicine_course_2013/Lecture%208/References/Derfus_2007.pdf
Targeted Quantum Dot Conjugates for siRNA Delivery Austin M. Derfus,†,‡ Alice A. Chen,§,3 Dal-Hee Min,§ Erkki Ruoslahti,‡,# and Sangeeta N. Bhatia*,†,§ Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, Burnham Institute for Medical
https://lmrt.mit.edu/publications/targeted-quantum-dot-conjugates-sirna-delivery
Using a PEGlyated quantum dot (QD) core as a scaffold, siRNA and tumor-homing peptides (F3) were conjugated to functional groups on the particle's surface. We found that the homing peptide was required for targeted internalization by tumor cells, and that siRNA cargo could be coattached without affecting the function of the peptide.
https://www.nature.com/articles/s41598-017-09555-w
Aug 25, 2017 · Cancer-targeted Nucleic Acid Delivery and Quantum Dot Imaging Using EGF Receptor Aptamer-conjugated Lipid Nanoparticles ... terms of cancer-targeted siRNA transfection and …Author: Min Woo Kim, Hwa Yeon Jeong, Seong Jae Kang, Moon Jung Choi, Young Myoung You, Chan Su Im, Tae Sup L...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835414/
Apr 18, 2016 · The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy ... Schematic representation of cationic nanoparticles for targeted delivery of siRNA-aptamer ... Jon S, Kantoff PW, Langer R, et al. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery ...Author: Mei-Xia Zhao, Bing-Jie Zhu
https://www.nanowerk.com/news/newsid=2413.php
Aug 22, 2007 · Targeting quantum dots to deliver SiRNA therapy ... ("Targeted Quantum Dot Conjugates for siRNA Delivery"), a team of investigators led by Sangeeta Bhatia, M.D., Ph.D., of the Massachusetts Institute of Technology, and Erkki Ruoslahti, M.D., Ph.D., of the Burnham Institute for Medical Research, both members of the NCI Alliance for ...
https://www.sciencedirect.com/science/article/pii/S0006291X0901314X
Functionalized silicon quantum dots tailored for targeted siRNA delivery ... Another approach for self-tracked delivery of siRNA was accomplished by Tan et ... E. Ruoslahti, S.N. BhatiaTargeted quantum dot conjugates for siRNA delivery. Bioconj. Chem., 18 (2007), pp. 1391-1396. Google Scholar. L.E. Rikans, T. YamanoMechanism of cadmium-mediated ...Author: S. Klein, O. Zolk, M.F. Fromm, F. Schrödl, W. Neuhuber, C. Kryschi
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