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https://www.slideshare.net/anushanagraj/targeted-drug-delivery-system
Sep 11, 2014 · INTRODUCTION : ‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
https://pubs.acs.org/doi/10.1021/jacs.0c00188
Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in vivo delivery of free drugs still constitutes a critical bottleneck. Herein, we report the design of a mitochondria-targeted metal–organic framework ...Author: Salame Haddad, Isabel Abanades Lazaro, Marcus Fantham, Ajay Mishra, Joaquin Silvestre-Albero, Johann...
https://www.researchgate.net/publication/297283078_Targeted_Drug_Delivery_A_Review
Targeted drug delivery, also known as smart drug delivery, is a method of treatment that involves the increase in medicament in one or few body parts in comparison to others. Two strategies are
https://www.academia.edu/9239676/TARGETED_DRUG_DELIVERY_SYSTEM
TARGETED DRUG DELIVERY SYSTEM
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047275/
Feb 26, 2020 · 2. Size Impact on Delivery Efficacy. As one of the most important characteristics of nanoparticles, size greatly influences the efficiency of tumor targeted drug delivery in many ways, including circulation, biodistribution, tumor accumulation and penetration, as well as cellular uptake and subcellular distribution.
https://www.sciencedirect.com/science/article/pii/S1369702105710336
The most promising application of in vivo targeted nanoparticle drug delivery currently involves readily accessible targets in the vasculature, such as malignant immune system cells. A second promising application is in local attachment via interventional catheterization …Author: Tarek M. Fahmy, Peter M. Fong, Amit Goyal, W. Mark Saltzman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184934/
A PSMA-positive prostate cancer cell line, LNCaP (PSMA +), was used as the model cell line, and a PSMA-negative prostate cancer cell line, PC3 (PSMA −), was used as a control to determine the specificity of the delivery system. The characteristics and anticancer effect of miRNA/PAMAM-PEG-APT were investigated in vitro.Author: Xin Wu, Baoyue Ding, Jing Gao, Huanyun Wang, Wei Fan, Xiang Wang, Wei Zhang, Xiaoyu Wang, Lihua Ye, ...
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/targeted-drug-delivery
4.2 Targeted Drug Delivery: Micellar Systems. Development of the nanosized polymeric micelles opens an all new method of targeted drug delivery system (Nasongkla et al., 2006).The small size, hydrophobic drug loading, long blood circulation time, biodegradable, less toxic, and in vivo stability makes them suitable candidates for targeted drug delivery (Uhrich et al., 1999).
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
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