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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911264/
May 11, 2010 · Exogenous targeting approaches have been widely used in the drug delivery field, both to improve drug potency and specificity. Specifically in the RNAi field, small molecules, 15,16 peptides, 17,18 proteins, 19 and antibodies 20 have been used to target LNPs to immune cells, tumor cells, and hepatocytes in vivo.Author: Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K Narayanannair Jayaprakash,...
https://www.sciencedirect.com/science/article/pii/S1525001616310814
Exogenous targeting approaches have been widely used in the drug delivery field, both to improve drug potency and specificity. Specifically in the RNAi field, small molecules, 15 , 16 peptides, 17 , 18 proteins, 19 and antibodies 20 have been used to target LNPs to immune cells, tumor cells, and hepatocytes in vivo.Author: Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K Narayanannair Jayaprakash,...
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)31081-4.pdf
Targeted Delivery of RNAi Therapeutics acquiring apoE9 and delivering siRNA to hepatocytes in a targeted manner (referred to as “endogenous targeting”). Alternatively, targeting may be achieved by the specific incorporation of a tar-geting ligand in the LNP (referred to as “exogenous targeting”).
https://www.sciencedirect.com/science/article/pii/S1550413118301827
Today, four RNA-targeted therapies are approved for commercial use for indications as diverse as Spinal Muscular Atrophy (SMA) and reduction of low-density lipoprotein cholesterol (LDL-C) and by routes of administration including subcutaneous, intravitreal, and intrathecal delivery.Author: Stanley T. Crooke, Joseph L. Witztum, C. Frank Bennett, Brenda F. Baker
https://www.researchgate.net/publication/49669080_Targeted_delivery_of_RNAi_therapeutics_for_cancer_therapy
Of special interest are RNAi-based drug target discovery and validation, delivery systems for RNAi-based drugs, such as nanoparticles, rabies virus protein-based vehicles, and bacteriophages for...
https://www.nature.com/articles/s41565-017-0043-5
Jan 29, 2018 · Yet, although major progress has been made in developing siRNA targeted delivery carriers, mainly by utilizing monoclonal antibodies (mAbs) for targeting …Author: Ranit Kedmi, Nuphar Veiga, Srinivas Ramishetti, Meir Goldsmith, Daniel Rosenblum, Niels Dammes, Inba...
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