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https://www.researchgate.net/publication/297283078_Targeted_Drug_Delivery_A_Review
Targeted drug delivery, also known as smart drug delivery, is a method of treatment that involves the increase in medicament in one or few body parts in comparison to others. Two strategies are
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/targeted-drug-delivery
Targeted drug delivery systems have improved cancer therapy drastically over the past decade (Kwon et al., 2012).Researchers have successfully developed cost-effective anticancer drugs mostly based on liposomes (Koning et al., 2010) and polymers (Rapoport, 2007).The basic principle of the operation of a targeted drug delivery is explained in Fig. 27.3.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · 2. A few observations on anticancer treatment. A typical in vitro study of targeted anticancer drug delivery is based on cultured human cancer cells which express a unique surface marker specifically selected to test the targeted delivery strategy being examined. Cytotoxicity is commonly examined by the addition of a drug delivery system directly to cells grown as a monolayer or in …Author: You Han Bae, Kinam Park
https://www.slideshare.net/anushanagraj/targeted-drug-delivery-system
Sep 11, 2014 · INTRODUCTION : ‘Targeted drug delivery system is a special form of drug delivery system where the medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells.’
https://www.sciencedirect.com/science/article/pii/S0939641120300175
Overexpression of certain surface cell receptors on cancer cells has revealed to be a promising tool for the development of active-targeted drug delivery nanosystems. Folic acid receptors and transferrin receptors are two of the most studied receptors in what concerns ligand-targeted payload delivery nanosystems as a cancer therapy strategy ...Author: Miguel Pereira-Silva, Carmen Alvarez-Lorenzo, Angel Concheiro, Ana Cláudia Santos, Francisco Veiga, ...
https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-5-70
Nov 09, 2012 · In parallel to naked TMAs, antibody-drug conjugates (ADCs) have been developed for targeted delivery of potent anti-cancer drugs with the aim of bypassing the morbidity common to conventional chemotherapy.Author: Michael A Firer, Gary Gellerman
https://drugdelivery.seas.harvard.edu/targeted-drug-delivery
Targeted drug delivery Our lab explores the effect of shape and deformability on performance of nanoparticles. We have shown that both shape and deformability impact various processes including circulation, adhesion and targeting, which we exploit for enhanced targeting.
https://pubs.acs.org/doi/10.1021/jacs.0c00188
Mitochondria play a key role in oncogenesis and constitute one of the most important targets for cancer treatments. Although the most effective way to deliver drugs to mitochondria is by covalently linking them to a lipophilic cation, the in vivo delivery of free drugs still constitutes a critical bottleneck. Herein, we report the design of a mitochondria-targeted metal–organic framework ...Author: Salame Haddad, Isabel Abanades Lazaro, Marcus Fantham, Ajay Mishra, Joaquin Silvestre-Albero, Johann...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508879/
In view of the recognized importance of targeted drug delivery strategies for cancer therapy, we discuss the advantages of alternative drug carriers and where these should be applied, focusing on peptide-drug conjugates (PDCs), particularly those discovered through combinatorial peptide libraries.Author: Michael A Firer, Gary Gellerman
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