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https://pubs.acs.org/doi/abs/10.1021/cb400095v
In this study, we explore this with a mitochondrially targeted form of the anticancer drug doxorubicin, which inhibits DNA topoisomerase II, an enzyme that is both in mitochondria and nuclei of human cells. When doxorubicin is attached to a peptide that targets mitochondria, it exhibits significant toxicity.Author: Graham R. Chamberlain, David V. Tulumello, Shana O. Kelley
https://www.ncbi.nlm.nih.gov/pubmed/23590228
Jul 19, 2013 · In this study, we explore this with a mitochondrially targeted form of the anticancer drug doxorubicin, which inhibits DNA topoisomerase II, an enzyme that is both in mitochondria and nuclei of human cells. When doxorubicin is attached to a peptide that targets mitochondria, it …Author: Graham R. Chamberlain, David V. Tulumello, Shana O. Kelley
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235738/
Furthermore, mitochondria-targeted delivery yielded substantial augmentation of functional biological and therapeutic effects in vitro and in vivo, as compared to controls that did not result in enrichment. This method is thus a platform for targeted drug delivery amenable to conjugation with a variety of molecules and not limited to cell ...Author: Yueqin Zheng, Xingyue Ji, Bingchen Yu, Kaili Ji, David Gallo, Eva Csizmadia, Mengyuan Zhu, Manjusha ...
https://www.nature.com/articles/s41557-018-0055-2
May 14, 2018 · Furthermore, mitochondria-targeted delivery yielded substantial augmentation of functional biological and therapeutic effects in vitro and in vivo when compared to …Author: Yueqin Zheng, Xingyue Ji, Bingchen Yu, Kaili Ji, David Gallo, Eva Csizmadia, Mengyuan Zhu, Manjusha ...
https://www.researchgate.net/publication/236204788_Targeted_Delivery_of_Doxorubicin_to_Mitochondria
This mitochondria-targeting strategy was effective in circumventing the resistance to doxorubicin in this cell line, an event the authors associated to the delivery of doxorubicin to this ...
https://www.sciencedirect.com/science/article/pii/B9780128177761000055
Mitochondria-targeted apocynin (Mito-Apo) were assimilated into polyanhydride NPs by a modified method called antisolvent nano-encapsulation , . Derivatization of the polyanhydride nanoparticles with folic acid (FA) was carried out through a two-step coupling reaction of …Author: Saravana Babu Chidambaram, Bipul Ray, Abid Bhat, Arehally Marappa Mahalakshmi, Tuladhar Sunanda, Pad...
https://www.dovepress.com/mitochondria-targeted-delivery-of-doxorubicin-to-enhance-antitumor-act-peer-reviewed-fulltext-article-IJN
Mitochondria-targeted delivery of doxorubicin to enhance antitumor activity with HER-2 peptide-mediated multifunctional pH-sensitive DQAsomes Menghao Shi,1 Jiulong Zhang,1 Xiaowei Li,1 Shuang Pan,1 Jie Li,2 Chunrong Yang,3 Haiyang Hu,1 Mingxi Qiao,1 Dawei Chen,1 Xiuli Zhao1 1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, People’s Republic of China ...Author: Menghao Shi, Jiulong Zhang, Xiaowei Li, Shuang Pan, Jie Li, Chunrong Yang, Haiyang Hu, Mingxi Qiao, ...
https://pubs.rsc.org/en/content/articlelanding/2019/ra/c9ra07096f#!
For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve the therapeutic effect. In this study, mitochondria-targeted and reduction-sensitive micelles were developed to co-deliver doxorubicin (DOX) and evodiamine (EVO
https://www.sciencedirect.com/science/article/pii/S1567724906002443
To realize a therapy for a mitochondrial disease, considerable efforts have focused on studies of drug delivery systems that are targeted to mitochondria as well as investigations of the molecular mechanism of mitochondrial diseases. In spite of great efforts, a universal strategy for therapies for mitochondrial diseases has not been established.Author: Yuma Yamada, Hidetaka Akita, Kentaro Kogure, Hiroyuki Kamiya, Hideyoshi Harashima
https://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra07096f
A mitochondria-targeted delivery system of doxorubicin and evodiamine for the treatment of metastatic breast cancer† Xiaoyan Tan, ‡* Yanlin Zhou,‡ Li Shen, Han Jia and Xiaorong Tan For mitochondria-targeted nano-drug delivery systems against cancer, effectively targeting and releasing the drug into mitochondria are the keys to improve ...Author: Xiaoyan Tan, Yanlin Zhou, Li Shen, Han Jia, Xiaorong Tan
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