T Cell Specific Sirna Delivery Suppresses Hiv-1 Infection

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T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943428/
    Aug 22, 2008 · However, the applicability of these approaches for siRNA delivery to primary T cells in HIV-1 infection remains untested. We used a single-chain antibody (scFv) to the pan-T cell surface protein CD7 (Peipp et al., 2002) a surface antigen present on the majority of human T cells.Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...

T cell-specific siRNA delivery suppresses HIV-1 infection ...

    https://www.ncbi.nlm.nih.gov/pubmed/18691745
    Aug 22, 2008 · Using a delivery method for T cells, we show that siRNA treatment can dramatically suppress HIV infection. A CD7-specific single-chain antibody was conjugated to oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in NOD/SCIDIL2rgamma-/- mice reconstituted with human lymphocytes (Hu-PBL) or CD34+ hematopoietic stem cells ...Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection ...

    https://www.cell.com/cell/fulltext/S0092-8674(08)00821-0
    Aug 22, 2008 · Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we show that siRNA treatment can dramatically suppress HIV infection. A CD7-specific single-chain antibody was conjugated to oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in ...Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection ...

    https://www.researchgate.net/publication/23160423_T_Cell-Specific_siRNA_Delivery_Suppresses_HIV-1_Infection_in_Humanized_Mice
    T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice Article in Cell 134(4):577-86 · September 2008 with 112 Reads How we measure 'reads'

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection ...

    http://europepmc.org/articles/PMC2943428
    Aug 01, 2008 · Another challenge is the delivery of siRNA to relevant cell types in vivo. Systemic delivery of siRNA to T cells, the major targets of HIV-1, is particularly difficult because they are resistant to siRNA uptake even by conventional lipid-based transfection in vitro (Goffinet and Keppler, 2006).

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection ...

    https://pediatrics.aappublications.org/content/124/Supplement_2/S156.2
    Nov 01, 2009 · Several small clinical trials using siRNAs are currently underway. This study represents a significant advance for 2 reasons: (1) the findings heighten the prospect of a new HIV-1/AIDS therapy and (2) this study provides a siRNA delivery system that might be adapted to target various receptors and thus other cell types.Author: Michael S. Tankersley

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