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https://www.ncbi.nlm.nih.gov/pubmed/18691745
Aug 22, 2008 · Comment in Cell. 2008 Aug 22;134(4):566-8. Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we show that siRNA treatment can dramatically suppress HIV infection.Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943428/
Aug 22, 2008 · Another challenge is the delivery of siRNA to relevant cell types in vivo. Systemic delivery of siRNA to T cells, the major targets of HIV-1, is particularly difficult because they are resistant to siRNA uptake even by conventional lipid-based transfection in vitro (Goffinet and Keppler, 2006).Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...
https://www.sciencedirect.com/science/article/pii/S0092867408008210
Aug 22, 2008 · Another challenge is the delivery of siRNA to relevant cell types in vivo. Systemic delivery of siRNA to T cells, the major targets of HIV-1, is particularly difficult because they are resistant to siRNA uptake even by conventional lipid-based transfection in vitro (Goffinet and Keppler, 2006).Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...
https://www.cell.com/cell/fulltext/S0092-8674(08)00821-0
Aug 22, 2008 · Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a delivery method for T cells, we show that siRNA treatment can dramatically suppress HIV infection. A CD7-specific single-chain antibody was conjugated to oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in ...Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...
https://www.nature.com/articles/ncomms13580
Nov 24, 2016 · Delivery of siRNA to target cells is essential for in vivogene therapy. Here the authors demonstrate an oligonucleotide aptamer that targets therapeutic siRNA to a specific cell type.Author: Kewei Ren, Ying Liu, Jie Wu, Yue Zhang, Jing Zhu, Min Yang, Huangxian Ju
https://pubs.acs.org/doi/10.1021/bc2006219
The intracellular delivery of small interfering RNA (siRNA) plays a key role in RNA interference (RNAi) and provides an emerging technique to treat various diseases, including infectious diseases. Chitosan has frequently been used in gene delivery applications, including siRNA delivery. However, studies regarding the modification of chitosan with antibodies specifically targeting T cells are ...Author: Jangwook Lee, Kyoung-Soo Yun, Chang Seon Choi, Seung-Hwa Shin, Hong-Seok Ban, Taiyoun Rhim, Sang Kyu...
https://www.researchgate.net/publication/23160423_T_Cell-Specific_siRNA_Delivery_Suppresses_HIV-1_Infection_in_Humanized_Mice
A CD7-specific single-chain antibody was conjugated to oligo-9-arginine peptide (scFvCD7-9R) for T cell-specific siRNA delivery in NOD/SCIDIL2rgamma-/- mice reconstituted with human lymphocytes ...
https://www.researchgate.net/publication/225046914_T_Cell-Specific_siRNA_Delivery_Using_Antibody-Conjugated_Chitosan_Nanoparticles
Omedes Pujol et al., 2013 Chitosan nanoparticles siRNA CD7 CD4 Jurkat and A3.01 N/A The effective suppression of CD4 receptors on the surface of T cells was achieved by anti-CD4 siRNA using T cell ...
https://pubs.acs.org/doi/abs/10.1021/bc2006219
Chitosan has frequently been used in gene delivery applications, including siRNA delivery. However, studies regarding the modification of chitosan with antibodies specifically targeting T cells are lacking. We hypothesized that chitosan nanoparticles modified with T cell-specific antibodies would be useful for delivering siRNA to T cells.Author: Jangwook Lee, Kyoung-Soo Yun, Chang Seon Choi, Seung-Hwa Shin, Hong-Seok Ban, Taiyoun Rhim, Sang Kyu...
https://pediatrics.aappublications.org/content/124/Supplement_2/S156.2
Nov 01, 2009 · Several small clinical trials using siRNAs are currently underway. This study represents a significant advance for 2 reasons: (1) the findings heighten the prospect of a new HIV-1/AIDS therapy and (2) this study provides a siRNA delivery system that might be adapted to target various receptors and thus other cell types.Author: Michael S. Tankersley
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