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http://europepmc.org/patents/PAT/US5344393
Use of synthetic oxygen carriers to facilitate oxygen delivery (PAT - US5344393) ROTH DUANE J, ... wherein the liquid comprises an effective oxygen-delivery enhancing amount of a biocompatible synthetic oxygen carrier, after which the patient undergoes a loss of blood, and then readministering blood to the patient, preferably the stored blood. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703868/
It is concluded that current blood substitutes development has amplified their applications horizon by devising therapeutic functions for oxygen carriers requiring limited O 2 delivery capacity restoration. Conversely, full, blood-like O 2 carrying capacity re-establishment awaits control of O 2 carrier toxicity.
https://authors.library.caltech.edu/25052/5/BioinCh_chapter4.pdf
eral synthetic oxygen carriers, especially of iron and cobalt porphyrins. In this chapter the structures and properties ofbiological and nonbiological oxygen car riers are described, with particular attention to the hemoglobin family. This family has been studied in more detail than any other group of proteins, and as
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084831/
Oct 27, 2016 · NO is also involved in relaxation of smooth muscles of blood vessels, and this property is responsible for the vasoactivity of Hb-based products.27 Overall, this type of Hb must be modified before its application as an oxygen carrier.4,16 The Hb-based oxygen carriers (HBOCs) are divided into the following two groups: acellular and cellular HBOCs.Author: Samira Moradi, Ali Jahanian-Najafabadi, Mehryar Habibi Roudkenar
https://www.acsh.org/wp-content/uploads/2012/04/20090721_blood_substitutes.pdf
Hemoglobin-Based Oxygen Carriers: THE AMERICAN COUNCIL ON SCIENCE AND HEALTH: Blood Substitutes: By Jerrold H. Levy, MD, FAHA ... The two major classes of oxygen-carrying blood substitutes studied are the HBOCs and perfluorocarbon (PFC) emulsions. ... and alterations in oxygen delivery are modulated by temperature, pH changes, or 2,3–diphos ...
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(16)30058-0.pdf
several attempts have been developed to supply sufficient oxygen for cells of damaged tissue. Examples of such attempts are using oxygen-rich fluids [such as perfluorocarbons (PFCs), silicone oils, and crosslinked hemoglobin] as oxygen carriers to facilitate the direct delivery
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