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https://www.researchgate.net/publication/244738118_Synergistic_Effect_of_Sonophoresis_and_Iontophoresis_in_Transdermal_Drug_Delivery
Synergistic Effect of Sonophoresis and Iontophoresis in Transdermal Drug Delivery. Synergistic effects of sonophoresis and iontophoresis on skin penetration were investigated using vitamin B12 (VB12 molecular weight 1355.4 and non-ionized compound at pH 7.4) as a model drug in the stratum corneum (SC) of hairless mice.
http://onlinelibrary.wiley.com/doi/10.1211/jpp.60.1.0004/abstract
Delivery was enhanced by iontophoresis and microneedles, both in‐vitro and in‐vivo. A synergistic 25‐fold enhancement of delivery was observed in‐vivo when a combination of microneedles and iontophoresis was used compared with either modality alone.
https://www.sciencedirect.com/science/article/pii/B9780815520252100046
Transdermal iontophoretic systems have the potential to enhance the delivery of drugs at levels that are therapeutically significant. They also enable the programming or control of the drug kinetics through the device, and therefore enhance patients' compliance.Author: Longsheng Hu, Priya Batheja, Victor Meidan, Bozena B. Michniak-Kohn
https://www.researchgate.net/profile/Samir_Mitragotri/publication/12124959_Mitragotri_S_Synergistic_effect_of_enhancers_for_transdermal_drug_delivery_Pharm_Res_17_1354-1359/links/553d7ac90cf29b5ee4bcc4ba/Mitragotri-S-Synergistic-effect-of-enhancers-for-transdermal-drug-delivery-Pharm-Res-17-1354-1359.pdf
Review Article Synergistic Effect of Enhancers for Transdermal Drug Delivery Samir Mitragotri1,2 Received May 20, 2000; accepted August 17, 2000 Transdermal drug delivery offers a non-invasive ...
http://www.ijps.ir/article_22797_9611a4aa9f90a7c2fe5f593406996549.pdf
transdermal patch by iontophoresis. The passive and electrically assisted transdermal delivery of Nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. Because of its extensive hepatic metabolism and low dose, Nebivolol hydrochloride become a suitableAuthor: Pavani Sriram, Madusudhan Rao Yamsani, Yamsani Shravan Kumar
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293348/
Dec 13, 2011 · Although iontophoresis provides many benefits and seems to be more effective than other techniques, there is a need for further research and judicious use of technology with microelectronics devices and to make it available for commercial application. Thus, iontophoresis may prove to be “a potential emergence to transdermal drug delivery”.
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