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https://www.ncbi.nlm.nih.gov/pubmed/22339074
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds.Author: Ankit I. Mehta, Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Past...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43312/
Mar 15, 1994 · We investigated convection as a means to enhance the distribution of the large and small molecules 111In-labeled transferrin (111In-Tf; M(r), 80,000) and [14C]sucrose (M(r), 359) over centimeter distances by maintaining a pressure gradient during interstitial infusion into white matter to generate bulk flow through the brain interstitium.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
Convection-enhanced delivery to brain parenchyma Accessibility of pharmacological agents from the bloodstream to the CNS meets with a formidable obstacle in the form of the BBB [ 1 ]. There is an absence of direct intracranial administration-only agents that are actively transported through the BBB or that are otherwise permeable through the barrier, which can directly kill tumor cells.Author: Waldemar Debinski, Stephen B Tatter
http://www.eurekaselect.com/103404/article
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds.Author: Ankit I. Mehta, Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Past...
https://www.researchgate.net/publication/221836741_Convection_Enhanced_Delivery_of_Macromolecules_for_Brain_Tumors
The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral...
https://www.academia.edu/11131148/Convection_Enhanced_Delivery_of_Macromolecules_for_Brain_Tumors
Convection Enhanced Delivery of Macromolecules for Brain Tumors
https://www.ncbi.nlm.nih.gov/pubmed/18076322
Convection-enhanced delivery is a promising method for the delivery of macromolecules to the CNS. Convection-enhanced delivery involves the infusion of therapeutic agents via surgically implanted catheters and uses a pressure gradient to achieve a greater volume of distribution compared with that seen with diffusion alone.Author: Sherise Desiree Ferguson, Kimberly Foster, Bakhtiar Yamini
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
Convection Enhanced Delivery. Using standard chemotherapy on brain tumors is challenging, considering that many of these drugs (administered as a pill, or injected intravenously) do not enter the brain easily. Increasing dosages would not work either, since these medications would reach toxic concentrations in the body before reaching effective...
https://www.ncbi.nlm.nih.gov/pubmed/19831841
Convection-enhanced delivery (CED) has been designed to overcome some of the difficulties so that pharmacological agents that would not normally cross the BBB can be used for treatment. Drugs are delivered through one to several catheters placed stereotactically directly within the tumor mass or around the tumor or the resection cavity.Author: Waldemar Debinski, Stephen B Tatter
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