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https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30322-X/fulltext
Convection-enhanced delivery has been proposed as a means to efficiently deliver therapeutic agents directly into the brainstem while minimising systemic exposure and associated toxic effects.Author: Mark M Souweidane, Mark M Souweidane, Kim Kramer, Kim Kramer, Neeta Pandit-Taskar, Neeta Pandit-Task...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327456/
Convection-enhanced delivery (CED) is a technique designed to deliver drugs directly into the brain or tumors. Its ability to bypass the blood-brain barrier (BBB), one of the major hurdles in delivering drugs to the brain, has made it a promising drug delivery method for the treatment of primary brain tumors.Author: Zhiping Zhou, Ranjodh Singh, Mark M. Souweidane
https://www.frontiersin.org/articles/10.3389/fonc.2019.00966/full
Convection-Enhanced Delivery to Drive Tissue Transport The guiding principle behind CED is creating a positive pressure gradient to deposit treatment directly into the tumor or resection cavity and drive it through the surrounding parenchyma such that invaded cells might be accessed.Author: Caleb A. Stine, Jennifer M. Munson
https://braintumorcenter.ucsf.edu/treatment/experimental-diagnostics-therapies/convection-enhanced-delivery
To address this problem, researchers at UCSF and elsewhere have been developing a procedure called convection-enhanced delivery (CED). CED is an experimental technique for directly infusing drugs into a brain tumor. This increases drug efficacy while reducing side effects to …
http://www.vetmed.vt.edu/clinical-trials/canine-glioma/convection-enhanced-delivery.asp
Convection Enhanced Delivery (CED) is a therapeutic strategy that was developed to facilitate targeted delivery of pharmaceuticals to the brain. The CED procedure involves a minimally invasive surgical exposure of the brain, followed by placement of small diameter catheters directly into the brain tumor.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657605/
Convection-enhanced delivery to brain parenchyma Accessibility of pharmacological agents from the bloodstream to the CNS meets with a formidable obstacle in the form of the BBB [ 1 ]. There is an absence of direct intracranial administration-only agents that are actively transported through the BBB or that are otherwise permeable through the barrier, which can directly kill tumor cells.Author: Waldemar Debinski, Stephen B Tatter
https://www.powershow.com/viewht/3f01b1-M2VjM/An_Overview_of_Glioblastoma_GBM_powerpoint_ppt_presentation
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