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https://pediatrics.aappublications.org/content/133/1/156
Jan 01, 2014 · Preterm Infants and Surfactant Effectiveness in Clinical Trials. Surfactant trials have included infants born between 23 and 34 weeks’ gestation and/or with birth weight between 500 and 2000 g. 1 – 12 The results of subgroup analyses from such studies indicated that surfactant therapy decreased mortality rates most effectively in infants born at less than 30 weeks’ gestation or with ...Author: Richard A. Polin, Waldemar A. Carlo, Newborn
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456838/
Surfactant will distribute to the preterm lung more uniformly when given rapidly and at higher volumes (see Table above). The slow infusion of surfactant into the lungs to minimize any acute physiological changes during treatment can result in very poor distribution. Using a slow rate of administration could result in a non-homogeneous surfactant distribution, which is not the desired outcome.Author: Nina Nouraeyan, Alicia Lambrinakos-Raymond, Marisa Leone, Guilherme Sant’Anna
https://pediatrics.aappublications.org/content/133/1/171
Current practice guidelines recommend administration of surfactant at or soon after birth in preterm infants with respiratory distress syndrome.
https://uichildrens.org/health-library/guidelines-surfactant-administration-surfactant-replacement-therapy
Etiology of surfactant inactivation or dysfunction: pulmonary hemorrhage, sepsis, pneumonia, meconium aspiration, and post surfactant slump. Surfactant replacement therapy for RDS - Early rescue therapy should be practiced: First dose needs to be given as soon as diagnosis of RDS is made. RDS in a premature infant is defined as respiratory distress requiring more than 30% oxygen delivered by ...
https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Surfactant_Administration_in_the_NICU/
Pulmonary surfactant is a complex mixture of phospholipids and proteins that creates a cohesive surface layer over the alveoli which reduces surface tension and maintains alveolar stability therefore preventing atelectasis. Surfactant deficiency is a recognized cause of respiratory distress syndrome in the preterm neonate.
https://www.healthline.com/health/pregnancy/premature-baby-lung-problems
Mar 15, 2012 · Preterm babies face a higher risk for one or more complications after delivery. One of the main concerns is the newborn’s lung. A baby’s lungs are typically considered mature by week 36.
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