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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993976/
Sep 11, 2008 · Stimuli-sensitive hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids.[1,2] These hydrogels exhibit a thermodynamic capability with water, which allow them to swell in aqueous media.[1–3] Hydrogels show a swelling behavior dependent on the external environment.These polymers are physiologically …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482766/
In ophthalmic drug delivery three types of stimuli-sensitive hydrogels - temperature sensitive, pH sensitive, and ion-sensitive hydrogels are mainly used. Table 1 explains the properties and mechanism of three types of hydrogels in brief. Details are discussed further.
https://www.researchgate.net/publication/232767020_Stimuli_sensitive_hydrogels_for_ophthalmic_drug_delivery_A_review
The present article describes the advantages and use stimuli sensitive of hydrogel systems in ophthalmic drug delivery. Discover the world's research 15+ million members
https://www.sciencedirect.com/science/article/pii/B9780128136898000069
Stimuli-sensitive hydrogels are good candidates to ophthalmic drug administration because they can improve the release behavior of the drug and increase the precorneal residency time of the drug increasing the therapeutic effect (Kushwaha et al., 2012, Meshram and Thorat, 2015).Author: Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro, Miguel González-Barcia, José Blanco-Méndez, Ast...
https://www.researchgate.net/publication/47450104_Stimuli-sensitive_hydrogels_A_novel_ophthalmic_drug_delivery_system
Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system Article (PDF Available) in Indian Journal of Ophthalmology 58(6):477-81 · March 2010 with 331 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/pii/S0169409X01002034
Thus, fast-acting hydrogels are necessary, and the easiest way of achieving that goal is to make thinner and smaller hydrogels. This usually makes the hydrogel systems too fragile and they do not have mechanical strength necessary in many applications. Environmentally sensitive hydrogels for drug delivery applications also require biocompatibility.Author: Yong Qiu, Kinam Park
http://ijpsr.com/bft-article/stimuli-sensitive-hydrogels-in-drug-delivery-systems/?view=fulltext
These stimuli sensitive hydrogel used in delivery of drug through various routs like oral, ophthalmic parenteral drug, nasal TDDS, and also in novel drug delivery like in nanoparticles. Now a day’s stimuli sensitive hydrogels are also used in administration of DNA.
https://link.springer.com/article/10.1007/s10792-018-0955-6
Jun 19, 2018 · Conventional dosage form like eye drops showed poor therapeutic response and also require frequent dosing. Therefore, developing the dosage form to deliver the drug to the target site without much loss of drug or without causing any systemic side effects is the challenging job for the researchers in pharmaceutical industries. The main aim of the present work was to formulate and …Author: S. Deepthi, Jobin Jose
https://www.azom.com/article.aspx?ArticleID=5895
Dec 14, 2011 · Hydrogels are three-dimensional polymer networks in which water can be imbibed at relatively high proportions. For a hydrogel to behave as a stimuli sensor and drug release actuator, its degree of cross-linking should be low enough to enable the polymeric network to undergo remarkable conformational changes due to the stimuli (namely swell/shrink), but high enough to maintain its …
http://www.ijo.in/text.asp?2010/58/6/477/71677
Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system Vinod Singh 1, SS Bushetti 2, Raju Appala 3, Adil Shareef 2, Syed S Imam 2, Mamta Singh 1 1 Department of Pharmaceutics & Pharmacology, SBS PG Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India 2 Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga, Karnataka, India 3 …
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