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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3482766/
In ophthalmic drug delivery three types of stimuli-sensitive hydrogels - temperature sensitive, pH sensitive, and ion-sensitive hydrogels are mainly used. Table 1 explains the properties and mechanism of three types of hydrogels in brief. Details are discussed further.
https://www.researchgate.net/publication/232767020_Stimuli_sensitive_hydrogels_for_ophthalmic_drug_delivery_A_review
Stimuli sensitive hydrogels for ophthalmic drug delivery: A review Article (PDF Available) in International Journal of Pharmaceutical Investigation 2(2):54-60 · April 2012 with 187 Reads
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993976/
Sep 11, 2008 · Stimuli-sensitive hydrogels are three-dimensional, hydrophilic, polymeric networks capable of imbibing large amounts of water or biological fluids.[1,2] These hydrogels exhibit a thermodynamic capability with water, which allow them to swell in aqueous media.[1–3] Hydrogels show a swelling behavior dependent on the external environment.These polymers are physiologically …
https://www.researchgate.net/publication/286499790_Stimuli_sensitive_hydrogels_A_review
Stimuli sensitive hydrogels: A review. ... Ophthalmic drug delivery systems are the challenging subject for the researchers because of delicate nature of ocular membrane and preventive barriers ...
https://www.sciencedirect.com/science/article/pii/B9780128136898000069
Stimuli-sensitive hydrogels are good candidates to ophthalmic drug administration because they can improve the release behavior of the drug and increase the precorneal residency time of the drug increasing the therapeutic effect (Kushwaha et al., 2012, Meshram and Thorat, 2015).Author: Francisco J. Otero-Espinar, Anxo Fernández-Ferreiro, Miguel González-Barcia, José Blanco-Méndez, Ast...
https://www.sciencedirect.com/science/article/pii/S0014305719314302
Temperature-sensitive hydrogels serve as attractive drug delivery system platforms for the encapsulation and sustained release of a range of therapeutic agents . Different mechanisms, such as passive diffusion, erosion, and swelling, dictate the release of the drugs from these thermoresponsive hydrogels . However, drug delivery systems based on ...Author: Dilshad Qureshi, Suraj Kumar Nayak, Samarendra Maji, Arfat Anis, Doman Kim, Kunal Pal
http://ijpsr.com/bft-article/stimuli-sensitive-hydrogels-in-drug-delivery-systems/?view=fulltext
These stimuli sensitive hydrogel used in delivery of drug through various routs like oral, ophthalmic parenteral drug, nasal TDDS, and also in novel drug delivery like in nanoparticles. Now a day’s stimuli sensitive hydrogels are also used in administration of DNA.
http://www.ijo.in/text.asp?2010/58/6/477/71677
Stimuli-sensitive hydrogels: A novel ophthalmic drug delivery system Vinod Singh 1, SS Bushetti 2, Raju Appala 3, Adil Shareef 2, Syed S Imam 2, Mamta Singh 1 1 Department of Pharmaceutics & Pharmacology, SBS PG Institute of Biomedical Sciences and Research, Dehradun, Uttarakhand, India 2 Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga, Karnataka, India 3 …
https://www.azom.com/article.aspx?ArticleID=5895
Dec 14, 2011 · Hydrogels are three-dimensional polymer networks in which water can be imbibed at relatively high proportions. For a hydrogel to behave as a stimuli sensor and drug release actuator, its degree of cross-linking should be low enough to enable the polymeric network to undergo remarkable conformational changes due to the stimuli (namely swell/shrink), but high enough to maintain its …
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