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https://www.sciencedirect.com/science/article/pii/S0939641102000619
Melt extrusion technology today represents an efficient pathway for the manufacture of drug delivery systems. Resulting products are mainly found amongst semi-solid and solid preparations. The potential of the technology is reflected in the wide scope of different dosage forms covering oral, parenteral and topical applications.Author: Jörg Breitenbach
https://www.sciencedirect.com/science/article/abs/pii/S0939641102000619
Starting from the plastic industry, today melt extrusion has found its place in the array of pharmaceutical manufacturing operations. This article reviews the process technology with regard to the set up and specific elements of the extruder as well as its application.Author: Jörg Breitenbach
https://www.researchgate.net/publication/11195846_Melt_extrusion_From_process_to_drug_delivery_technology
Melt extrusion is a solvent-free process that allows high drug loading as well as content uniformity (Breitenbach, 2002 Dry emulsions are powdery, lipid-based formulations from which an O/W ...Author: Jörg Breitenbach
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543799/
Dec 27, 2012 · In addition to being a proven manufacturing process, HME meets the goal of the US Food and Drug Administration's (FDA) process analytical technology (PAT) scheme for designing, analyzing, and controlling the manufacturing process via quality control measurements during active extrusion process . In this chapter, the hot-melt extrusion technique ...Author: Mohammed Maniruzzaman, Joshua S. Boateng, Martin J. Snowden, Dennis Douroumis
https://www.researchgate.net/publication/265004302_Hot-melt_extrusion_technology_Optimizing_drug_delivery
Hot-melt extrusion technology: Optimizing drug delivery Article (PDF Available) in European Journal of Parenteral and Pharmaceutical Sciences 15(2) · January 2010 with 816 Reads How we measure ...
https://www.azolifesciences.com/article/Hot-Melt-Extrusion-in-the-Pharmaceutical-and-Food-Industries.aspx
Another advantage is the ability to incorporate analytical technology for a quality-by-design approach for continuous manufacturing; in turn, hot melt extrusion has been classified as meeting the U.S. Food and Drug Administration (FDA) goals for the design, analysis and quality control of the active extrusion process. The process of hot melt ...
https://www.deliveryscience.com/pharmaceutical-hot-melt-extrusion/explanation-of-process/
Foster Delivery Science’s pharmaceutical hot melt extrusion is performed in a cGMP production facility using single and twin screw extruders qualified and designed for drug delivery applications. Our equipment and extruders allow us to work with as little as 3-10 gram batches of material for proof of concept and early formulation development.
http://www.americanpharmaceuticalreview.com/Featured-Articles/37185-Process-Development-Scaling-a-Melt-Extrusion-Process-from-Conception-to-Commercialization/
Mar 01, 2011 · As a well-established process technology that has been developed and optimized over the past century, hot melt extrusion has become a staple of the plastics and food industries while continuing to gain prominence in the pharmaceutical industry. Melt extrusion has become a popular route for increasing the bioavailability of poorly soluble compounds owing to its role as a process technology …Author: Michael Lowinger
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