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https://www.ncbi.nlm.nih.gov/pubmed/22968416
Nov 07, 2012 · Spatiotemporally controlled delivery of soluble factors for stem cell differentiation. Kawada J(1), Kimura H, Akutsu H, Sakai Y, Fujii T. Author information: (1)Institute of Industrial Science, University of Tokyo, Tokyo, Japan.Author: Jiro Kawada, Hiroshi Kimura, Hidenori Akutsu, Yasuyuki Sakai, Teruo Fujii
https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc40268h
By adopting a porous membrane with relatively large pores, patterned delivery of soluble factors is maintained stably over a period of time long enough for cell differentiation. We report that spatial patterns of mouse induced pluripotent stem cells (miPSCs) differentiation can be …Author: Jiro Kawada, Hiroshi Kimura, Hidenori Akutsu, Yasuyuki Sakai, Teruo Fujii
https://www.researchgate.net/publication/230832898_Spatiotemporally_controlled_delivery_of_soluble_factors_for_stem_cell_differentiation
Spatiotemporally controlled delivery of soluble factors for stem cell differentiation Article in Lab on a Chip 12(21):4508-15 · September 2012 with 38 Reads How we measure 'reads'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712932/
Jan 14, 2008 · Most of the studies investigating stem cell differentiation have been performed on 2D plates coated with various biomaterials. Precise spatial and temporal presentation of factors directing the stem cell differentiation is extremely important to achieve homogeneous and efficient differentiation.Author: Nathaniel S. Hwang, Shyni Varghese, Jennifer Hartt Elisseeff
https://www.nature.com/articles/srep04462
Mar 25, 2014 · We demonstrate the spatiotemporally controlled neuronal commitment of mouse embryonic stem cells via delivery of retinoic acid gradients. …Author: S. Cosson, M. P. Lutolf
https://www.sciencedirect.com/science/article/pii/S0169409X07002438
Tissue engineering scheme of utilizing stem cells. Basic building blocks of tissue engineering include scaffolds, bioactive factors, along with stem cells. Stem cell differentiation, cell-self organization, ECM synthesis, and remodeling would result tissues due to close interactions between the cells, scaffolds, and bioactive factors.Author: Nathaniel S. Hwang, Shyni Varghese, Jennifer Hartt Elisseeff
https://www.nature.com/articles/s41592-019-0455-2
Jun 27, 2019 · Titmarsh, D. M. et al. Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS ONE 7 , e52405 (2012). CASAuthor: Andrea Manfrin, Yoji Tabata, Eric R. Paquet, Ambroise R. Vuaridel, François R. Rivest, Felix Naef, M...
https://stemcellres.biomedcentral.com/articles/10.1186/scrt415
Soluble factors secreted by differentiating embryonic stem cells stimulate exogenous cell proliferation and migration ... The objective of this study was thus to determine the relative abundance of specific soluble factors secreted by ESCs as a function of differentiation and to examine the effects of these ESC-derived factors on exogenous cell ...Author: Alyssa V Ngangan, James C Waring, Marissa T Cooke, Christian J Mandrycky, Todd C McDevitt, Todd C Mc...
https://www.cirm.ca.gov/our-progress/stem-cell-differentiation-and-microenvironment
Students will learn about stem cell differentiation (also known as specialization) into lineages, creating multiple cell types that together contribute to the development, function, and maintenance of organs and body systems. A stem cell’s microenvironment contributes to its differentiation path.
http://europepmc.org/articles/PMC3964519
In vivo, these factors are presented in a spatiotemporally tightly controlled fashion. Although state-of-the-art microfluidic technologies allow precise biomolecule delivery in time and space, long-term (stem) cell culture at the micro-scale is often far from ideal due to medium …
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