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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835857/
Oct 01, 2008 · In this work a mathematical model was developed to describe the delivery and penetration of nanoparticle drug carriers to multicellular spheroids taking into account structural changes in the spheroid in the radial direction.Author: Thomas T. Goodman, Jingyang Chen, Konstantin Matveev, Suzie H. Pun
https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/bit.21910
Mar 24, 2008 · Recent work has indicated that modulation of tissue architecture with enzymes such as collagenase significantly increases macromolecule delivery. In this study we developed a mathematical model of nanoparticle penetration into multicellular spheroids that accounts for radially dependent changes in tumor architecture, as represented by the volume fraction of tissue accessible to nanoparticle diffusion.Author: Thomas T. Goodman, Jingyang Chen, Konstantin Matveev, Suzie H. Pun
http://onlinelibrary.wiley.com/doi/10.1002/bit.21910/abstract
Unknown parameters of nanoparticle binding sites per cell in the spheroid and pore shape factor were determined by fitting to experimental data. The model was correlated with experimental studies of the penetration of 40 nm nanoparticles in SiHa multicellular spheroids with and without collagenase treatment and was able to accurately predict concentration profiles of nanoparticles within spheroids. The model was also used to investigate the effects of nanoparticle size. This model ...
https://www.researchgate.net/publication/5348988_Spatio-Temporal_Modeling_of_Nanoparticle_Delivery_to_Multicellular_Tumor_Spheroids
Request PDF Spatio-Temporal Modeling of Nanoparticle Delivery to Multicellular Tumor Spheroids The inefficiency of nanoparticle penetration in tissues limits the therapeutic efficacy …
https://www.deepdyve.com/lp/wiley/spatio-temporal-modeling-of-nanoparticle-delivery-to-multicellular-FvFZGmCc20
Oct 01, 2008 · Spatio‐temporal modeling of nanoparticle delivery to multicellular tumor spheroids Recent work has indicated that modulation of tissue architecture with enzymes such as collagenase significantly increases macromolecule delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615073/
The results clearly depict 1) the limitation of nanoparticle delivery in the local tumor tissues, 2) the treatable domain for a nanoparticle when the tumor and particle properties are given, and 3) the potential improvement when vascular permeability, interstitial diffusivity and half-life in …Author: Cheng-Ying Chou, Chih-Kang Huang, Kuo-Wei Lu, Kuo-Wei Lu, Tzyy-Leng Horng, Win-Li Lin, Win-Li Lin
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-15
Jan 13, 2012 · The multicellular tumor spheroid (MCTS) is an in vitro model associating malignant-cell microenvironment and 3D organization as currently observed in avascular tumors. In order to evaluate the relevance of this model for pre-clinical studies of drug combinations, we analyzed the effect of gemcitabine alone and in combination with the CHIR-124 CHK1 inhibitor in a Capan-2 pancreatic cell …Author: Isabelle Dufau, Céline Frongia, Flavie Sicard, Laure Dedieu, Pierre Cordelier, Frédéric Ausseil, Ber...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(16)30293-1
Jan 01, 2014 · Multicellular Tumor Spheroids as a Model for Assessing Delivery of Oligonucleotides in Three Dimensions Previous Article Hepatic Monoacylglycerol O-acyltransferase 1 as a Promising Therapeutic Target for Steatosis, Obesity, and Type 2 DiabetesAuthor: Kyle Carver, Xin Ming, Rudolph L Juliano
https://www.sciencedirect.com/science/article/pii/S0168365917310623
Development of multicellular tumor spheroid models makes it possible to evaluate tumor-targeted drug delivery systems in a 3D environment in vitro that resembles tumor microenvironment in humans. Delivery barriers created for those systems such as ECM barrier deposition, tumor heterogeneity together with cell–cell interactions between different cells, and gradients of oxygen and acid, can be retained in spheroids.Author: Bu-Wei Huang, Bu-Wei Huang, Jian-Qing Gao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947376/
In this study we use a tumour-on-a-chip system to evaluate the roles of NP diameter, receptor-targeting and flow conditions on nanoparticle (NP) transport within a model tumor tissue. We demonstrate that NP tissue accumulation is restricted to hydrodynamic diameters <110 nm with receptor-targeting improving accumulation and retention.Author: Alexandre Albanese, Alan K. Lam, Alan K. Lam, Edward A. Sykes, Jonathan V. Rocheleau, Jonathan V. Ro...
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