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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835857/
Oct 01, 2008 · For effective nanoparticle treatment to tumor tissue, we suggest that a tumor modulating agent, such as collagenase, may significantly improve efficiency of nanoparticle delivery. Nanoparticle carriers can be designed for inclusion of such an adjuvant, as has already been demonstrated with collagenase (Kuhn et al., 2006). Even with this inclusion of an adjuvant it is still ideal to have a nanoparticle carrier …Cited by: 134
http://onlinelibrary.wiley.com/doi/10.1002/bit.21910/abstract
The model was correlated with experimental studies of the penetration of 40 nm nanoparticles in SiHa multicellular spheroids with and without collagenase treatment and was able to accurately predict concentration profiles of nanoparticles within spheroids. The model was also used to investigate the effects of nanoparticle size.
https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/bit.21910
Mar 24, 2008 · Recent work has indicated that modulation of tissue architecture with enzymes such as collagenase significantly increases macromolecule delivery. In this study we developed a mathematical model of nanoparticle penetration into multicellular spheroids that accounts for radially dependent changes in tumor architecture, as represented by the volume fraction of tissue accessible to nanoparticle diffusion.Cited by: 134
https://www.researchgate.net/publication/5348988_Spatio-Temporal_Modeling_of_Nanoparticle_Delivery_to_Multicellular_Tumor_Spheroids
Modelling of nanoparticle delivery to multicellular spheroids showed that particle size, binding rate and porosity were key factors for designing nanoparticle-drug carriers [56]. Another study of ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615073/
The results clearly depict 1) the limitation of nanoparticle delivery in the local tumor tissues, 2) the treatable domain for a nanoparticle when the tumor and particle properties are given, and 3) the potential improvement when vascular permeability, interstitial diffusivity and half-life in …Cited by: 7
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-73
Feb 08, 2013 · MultiCellular Tumor Spheroid (MCTS) mimics the organization of a tumor and is considered as an invaluable model to study cancer cell biology and to evaluate new antiproliferative drugs. Here we report how the characteristics of MCTS in association with new technological developments can be used to explore the regionalization and the activation of cell cycle checkpoints in …Cited by: 82
https://www.sciencedirect.com/science/article/pii/S0378517314000209
Overall, BCM penetration was found to depend on nanoparticle size, time and tumor and spheroid cell line. Therefore, the design of effective nanomedicines will require careful tailoring of nanoparticle properties, such as their size, in order to mitigate tumor tissue-specific restrictions on …Cited by: 50
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673974/
Nanoparticle delivery to multicellular spheroids. Spheroids with diameters between 400–500 μm were obtained after approximately 10–14 days of growth. For each experiment, ~30 spheroids were handpicked with a Pasteur pipette and transferred to a 1.5 ml siliconized tube. Media was exchanged to OptiMEM reduced serum media (Gibco, Grand Island, NY).Cited by: 272
https://www.sciencedirect.com/science/article/pii/S0168365917310623
These models include tumor tissue explant models, scaffold-based models, microfluidic models and multicellular tumor spheroids . Among all the models used for 3D tumor cultures, multicellular tumor spheroid (MCTS) models have attracted great attention and have been broadly utilized in anti-cancer drug research [21] .Cited by: 19
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