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https://www.sciencedirect.com/science/article/pii/S0168365918300774
The block copolymer VIPER (virus-inspired polymer for endosomal release) has been reported to be a promising novel delivery system of DNA plasmids both in vitro and in vivo.VIPER is comprised of a polycation segment for condensation of nucleic acids as well as a pH-sensitive segment that exposes the membrane lytic peptide melittin in acidic environments to facilitate endosomal escape.Author: Daniel P. Feldmann, Yilong Cheng, Rima Kandil, Yuran Xie, Mariam Mohammadi, Hartmann Harz, Akhil Sha...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198620/
Polyethylenimine. Though PEI is known as the gold standard for plasmid DNA (pDNA) delivery its effectiveness in siRNA delivery is considered to be far less pronounced (Hassani et al., 2005; Grayson et al., 2006).The reduced efficacy of PEI in the later case arises due to the short length of siRNA.Author: Kaushik Singha, Ran Namgung, Won Jong Kim
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The currently developed siRNA delivery systems for cancer therapy can be divided into four categories: chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others (exosomes, RNAi-microsponges, oligonucleotide nanoparticles).Author: Cong-fei Xu, Jun Wang
https://pubs.acs.org/doi/10.1021/acsbiomaterials.6b00363
The number of polymer-based vectors for siRNA delivery in clinical trials lags behind other delivery strategies; however, the molecular architectures and chemical compositions available to polymers make them attractive candidates for further exploration. Polymer vectors are extensively investigated in academic laboratories worldwide with fundamental progress having recently been made in the ...Author: Bailey M. Cooper, David Putnam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · There have been several excellent recent reviews on siRNA delivery, with in-depth discussion usually on a specific system (e.g., siRNA conjugates, lipid-based siRNA delivery, polymer nanocarriers, and peptide transduction domains and cell-penetrating peptide) (4–7) or specialized delivery techniques (e.g., hydrodynamic intravascular injection ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://pubs.acs.org/doi/10.1021/acs.nanolett.9b01660
Herein, a unique polymer–prodrug hybrid NP platform was developed for multistage siRNA delivery and combination cancer therapy. This NP system is composed of (i) a hydrophilic polyethylene glycol (PEG) shell, (ii) a hydrophobic NP core made with a tumor microenvironment (TME) pH-responsive polymer, and (iii) charge-mediated complexes of siRNA ...Author: Phei Er Saw, Herui Yao, Chunhao Lin, Wei Tao, Omid C Farokhzad, Xiaoding Xu
https://www.sigmaaldrich.com/technical-documents/articles/material-matters/delivery-of-nucleic-acids-using-polymers.html
Delivery of Nucleic Acids Using Polymers. By: Olivia Merkel, Material Matters ... another parameter that is crucially important in the development of polymeric siRNA delivery systems. 44 ... (ethyleneimine) (PEI) has been a prominent polymer used in the development of three areas in particular: non-viral transfection, targeted delivery, and ...
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