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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939975/
Jul 05, 2016 · This siRNA-based revolutionary approach can soon come to the market, depending on the results of several active Phase III clinical trials.5,6 This review will focus on siRNA delivery by lipid nanoparticles (LNPs) and the current status of clinical trials for these systems. In the first section, we will describe the different components forming ...Author: Timofei S Zatsepin, Yuri V Kotelevtsev, Victor Koteliansky
https://www.sciencedirect.com/science/article/pii/S0378517317302880
Quantitative monitoration of the disassembly of siRNA containing nanoparticles, even in full serum, should be considered when developing of siRNA polyplexes and other nanoparticulate nucleic acid delivery systems as well: the amount of siRNA still retained in the polyplexes in a particular medium will, in some extent, be predictive of the gene ...Author: Gennara Cavallaro, Carla Sardo, Emanuela Fabiola Craparo, Barbara Porsio, Gaetano Giammona
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · In order to develop efficacious, degradable nanoparticles for siRNA delivery while conducting structure–function analysis, we first employed Michael addition chemistry to …Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964096/
Mar 18, 2014 · Nonetheless, the efficient, selective, and safe delivery of siRNA to hepatocytes is still a key challenge to the broad application of siRNA therapeutics to liver diseases . Biomimetic and bioinspired nanomaterials, such as exosomes and lipoprotein particles, have attracted extensive interest for a variety of applications including drug delivery ...Author: Yizhou Dong, Yizhou Dong, Kevin T. Love, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yu...
https://pubs.acs.org/doi/10.1021/nn502125h
Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells. Journal of Controlled Release 2019, 295, 268-277. DOI: 10.1016/j.jconrel.2019.01.006. Dian-Jang Lee, Ernst Wagner.Author: Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi,...
https://www.nature.com/articles/nnano.2012.73
In vivo, these nanoparticles showed a longer blood circulation time (t 1/2 ≈ 24.2 min) than the parent siRNA (t 1/2 ≈ 6 min). Access through your institution Buy or subscribeAuthor: Hyukjin Lee, Hyukjin Lee, Abigail K. R. Lytton-Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanou...
https://www.sciencedirect.com/science/article/abs/pii/S0168365916303224
Nano in nanoparticles: SEM images of intact double nano carriers (DNCs) (left) and a fractured DNC (following freeze-fracture process), showing the inner structure (right).Left insert shows the general architecture of pegylated DNCs and right insert is a zoom-in of the inner matrix of the DNCs, composed of polymeric PLGA fibers with HSA PNPs (~ 100 nm) embedded within them.Author: Orit Amsalem, Taher Nassar, Sandrine Benhamron, Philip Lazarovici, Simon Benita, Eylon Yavin
https://pubs.acs.org/doi/abs/10.1021/nl304287a
Coated nanoparticles are capable of delivering DNA and siRNA to cells in culture. The mean hydrodynamic size of these nanoparticles was systematically varied and optimized for delivery. While nanoparticles of different sizes showed similar siRNA delivery efficiency, nanoparticles of 50–100 nm displayed optimal DNA delivery activity.Author: Shan Jiang, Ahmed A. Eltoukhy, Kevin T. Love, Robert Langer, Daniel Griffith Anderson
https://www.hindawi.com/journals/jnm/2011/742895/
Despite the powerful therapeutic potential of siRNA, there are challenges for developing efficient and specific delivery systems for systemic administration. There are extracellular and intracellular barriers for nanoparticle-mediated delivery. First, nanoparticles are rapidly cleared from the circulation by the reticuloendothelial system (RES).Author: Shutao Guo, Leaf Huang
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
Jul 29, 2019 · The delivery of siRNA using polymeric-based nanoparticles (e.g. PEI) can exhibit severe toxicity towards different cell lines. It was found that the increasing the number of cationic groups or the concentration of the delivery system increased the toxicity level.Author: Waleed M. Hussein, Waleed M. Hussein, Yee S. Cheong, Chang Liu, Genan Liu, Anjuman Ara Begum, Maria ...
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