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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939975/
Jul 05, 2016 · This siRNA-based revolutionary approach can soon come to the market, depending on the results of several active Phase III clinical trials.5,6 This review will focus on siRNA delivery by lipid nanoparticles (LNPs) and the current status of clinical trials for these systems. In the first section, we will describe the different components forming ...Author: Timofei S Zatsepin, Yuri V Kotelevtsev, Victor Koteliansky
https://www.hindawi.com/journals/bmri/2013/782041/
Currently, there are six cancer clinical trials underway using nanoparticle-based siRNA delivery, all in Phase I, evaluating the initial safety and utility of these treatments (Table 1). All the nanoparticle-formulated siRNA delivery systems for cancer therapy that are currently in clinical trials are based on polymers or liposomes.Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409786/
Jul 24, 2012 · Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. ... Therefore, we hypothesized that siRNA-based SNA gold nanoparticle conjugates might be ideal topical delivery agents to treat diseases of the skin. Results.Author: Dan Zheng, Dan Zheng, David A. Giljohann, David A. Giljohann, David L. Chen, Matthew D. Massich, Mat...
https://www.sciencedirect.com/science/article/pii/S1040842815300639
Consequently, encapsulation of siRNA with nanoparticles will help shield the siRNA from plasmatic nucleases and immune responses thus assisting in endocytosis and successful siRNA delivery. Furthermore ligand bound nanoparticles increase selectivity of nanoparticle delivery of siRNA to tumour cells (Resnier et al., 2013).Author: Samuel Wang Sherng Young, Martina Stenzel, Yang Jia-Lin
https://www.sciencedirect.com/science/article/pii/S1549963418300807
We are investigating the role of TWIST in mediating these relapses. We demonstrate TWIST-siRNA (siTWIST) and a novel nanoparticle delivery platform to reverse chemoresistance in an EOC model. Hyaluronic-acid conjugated mesoporous silica nanoparticles (MSN-HAs) carried siTWIST into target cells and led to sustained TWIST knockdown in vitro. Mice ...Author: Sophia A. Shahin, Ruining Wang, Shirleen I. Simargi, Shirleen I. Simargi, Altagracia Contreras, Alta...
https://www.sigmaaldrich.com/life-science/functional-genomics-and-rnai/sirna/nter.html
Sigma’s N-TER Nanoparticle siRNA Transfection System is based on a peptide transfection reagent specifically designed to bypass these limitations and allow for efficient delivery of siRNAs into these historically recalcitrant eukaryotic cell types.
https://pubs.acs.org/doi/10.1021/acs.nanolett.8b01101
Although mRNA and siRNA have significant therapeutic potential, their simultaneous delivery has not been previously explored. To facilitate the treatment of diseases associated with aberrant gene upregulation and downregulation, we sought to co-formulate siRNA and mRNA in a single lipidoid nanoparticle (LNP) formulation. We accommodated the distinct molecular characteristics of mRNA …Author: Rebecca L. Ball, Khalid A. Hajj, Jamie Vizelman, Palak Bajaj, Kathryn A. Whitehead
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