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https://www.ncbi.nlm.nih.gov/pubmed/21423189
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255578/
Delivery of siRNA exclusively to the endothelial cells of the lung may indicate direct transfer of the nanocomplexes from circulation to the cells lining the capillary bed.Author: Kevin J Polach, Majed Matar, Jennifer Rice, Gregory Slobodkin, Jeff Sparks, Richard Congo, Angela Re...
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a …Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://altogen.com/InVivoTransfection3.pdf
siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer’s disease, in wild-type mice. Despite recent advances in delivering siRNA, targeting specific tissues or cell types while avoiding nonspecific delivery, especially to the liver, remains challenging.
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/performing-rnai-experiments-in-animals.html
More recently, low volume, normal pressure intravenous delivery of a modified siRNA targeting apolipoprotein B in mice resulted in gene silencing in the liver and jejunum. The siRNA was conjugated with cholesterol to provide targeted delivery, and included backbone and sugar modifications to enhance serum stability [6].
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · Here we show how exosomes derived from cultured cells can be harnessed for delivery of siRNA in vitro and in vivo. This protocol first describes the generation of targeted exosomes …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://bmcophthalmol.biomedcentral.com/articles/10.1186/1471-2415-10-25
Single intravitreal injection of as little as 5 ng of siRNA combined with Transit-TKO transfection reagent by a modified protocol provided robust and non-toxic delivery of the siRNA into the retina. However, siRNA accumulation was predominantly confined to ganglion cells layer as analysed 24 h post-injection.
https://www.nature.com/articles/nbt.1830
Apr 08, 2011 · A natural system for ferrying RNA between cells is used to transport siRNA to the mouse brain. ... Advantages and drawbacks of siRNA delivery by …Author: Jasper G van den Boorn, Martin Schlee, Christoph Coch, Gunther Hartmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174/
Aug 11, 2014 · We have used α-Syn small interfering RNA (siRNA) to reduce total and aggregated α-Syn levels in mouse brains. To achieve widespread delivery of siRNAs to the brain we have peripherally injected modified exosomes expressing Ravies virus glycoprotein loaded with siRNA. Normal mice were analyzed 3 or 7 days after injection.Author: JM Cooper, PB Wiklander, JZ Nordin, R Al-Shawi, MJ Wood, M Vithlani, AH Schapira, JP Simons, S El-An...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The siRNA-loaded nanoparticles, known as Micelleplex, can be effectively internalized and subsequently release siRNA into cells, resulting in significant gene knockdown activity, which was demonstrated by delivering two siRNAs targeting green fluorescence protein (GFP) that effectively silenced GFP expression in 40–70% of GFP-expressing HEK293 cells . mPEG-b-PCL-b-PPEEA has also been used …Author: Cong-fei Xu, Jun Wang
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