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https://www.ncbi.nlm.nih.gov/pubmed/21320582
Sep 20, 2011 · Carbon nanotubes (CNTs) have been studied for drug, antigen and nucleic acid delivery both in vitro and in vivo. Due to their nano-needle structure, they are supposed to cross the plasma membrane and enter directly into the cytoplasm likely upon an endocytosis-independent mechanism without inducing cell death.Author: Amir Khashayar Varkouhi, Stéphanie Foillard, Twan Lammers, Twan Lammers, Raymond M. Schiffelers, Eri...
https://www.sciencedirect.com/science/article/pii/S0378517311001256
Sep 20, 2011 · Carbon nanotubes (CNTs) have been studied for drug, antigen and nucleic acid delivery both in vitro and in vivo. Due to their nano-needle structure, they are supposed to cross the plasma membrane and enter directly into the cytoplasm likely upon an endocytosis-independent mechanism without inducing cell death.Author: Amir Khashayar Varkouhi, Stéphanie Foillard, Twan Lammers, Twan Lammers, Raymond M. Schiffelers, Eri...
https://www.researchgate.net/publication/49835600_SiRNA_delivery_with_functionalized_carbon_nanotubes
The conjugation of siRNA to functionalized carbon nanotubes (f-CNTs) significantly increases their delivery into cells due to CNT uptake through mechanisms other than endocytosis.
https://pubs.acs.org/doi/10.1021/jp312416d
Carbon nanotubes internalize into cells and are potential molecular platforms for siRNA and DNA delivery. A comprehensive understanding of the identity and stability of ammonium-functionalized carbon nanotube (f-CNT)-based nucleic acid constructs is critical to deploying them in vivo as gene delivery vehicles.
http://onlinelibrary.wiley.com/doi/10.1002/anie.200604295/full
Special delivery: Functionalized single‐walled nanotubes (SWNT) can be used as molecular transporters to shuttle short interfering RNA (siRNA) into human T cells and primary cells and silence the expression of HIV‐specific cell‐surface receptors and coreceptors (see picture; scale bars 40 μm). This silencing effect, known to block HIV viral entry and reduce infection, is superior to that observed with …
https://www.sciencedirect.com/science/article/pii/S0142961213015755
RNAi can specifically regulate gene expression, but efficient delivery of siRNA in vivo is difficult while it has been shown that modified carbon nanotubes (CNT) protect siRNA, facilitate entry into cells and enhance transdermal drugs delivery. Single-walled carbon nanotubes (SWCNT) were functionalized non-covalently with succinated polyethyleimine (PEI-SA).Author: King Sun Siu, Di Chen, Xiufen Zheng, Xusheng Zhang, Nathan Johnston, Yanling Liu, Ken Yuan, James Ko...
https://pubs.acs.org/doi/abs/10.1021/bc500280q
Modified carbon nanotubes (CNTs) have been shown to protect siRNA and facilitate its entry into cells. However, simple and efficient methods to functionalize CNTs are needed. Here, noncovalent functionalization of CNTs is performed and shown to effectively deliver siRNA to target cells.Author: King S. Siu, Xiufen Zheng, Yanling Liu, Yujuan Zhang, Xusheng Zhang, Di Chen, Ken Yuan, Elizabeth R....
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