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https://www.nature.com/articles/nbt.1830
Apr 08, 2011 · Endosomal escape of PEI-siRNA or lipid nanoparticles leads to cytosolic delivery of the siRNA, mediating temporary RNAi. However, rupture or leakage of the endosomal/lysosomal membrane in most cases will be associated with cathepsin B release and …Author: Jasper G van den Boorn, Martin Schlee, Christoph Coch, Gunther Hartmann
https://www.ncbi.nlm.nih.gov/pubmed/21478846
1. Nat Biotechnol. 2011 Apr;29(4):325-6. doi: 10.1038/nbt.1830. SiRNA delivery with exosome nanoparticles. van den Boorn JG, Schlee M, Coch C, Hartmann G.Author: Jasper G van den Boorn, Martin Schlee, Christoph Coch, Gunther Hartmann
https://www.researchgate.net/publication/51037796_SiRNA_delivery_with_exosome_nanoparticles
SiRNA delivery with exosome nanoparticles Jasper G van den Boorn, Martin Schlee, Christoph Coch & Gunther Hartmann A natural system for ferrying RNA between cells is used to transport siRNA …
https://www.sciencedirect.com/science/article/pii/S0304383519300837
Milk exosomes represent a viable natural nano-carrier for the delivery of siRNA. Exosomes were loaded with siRNA using a chemical transfecting reagent, Exo-Fect. siRNA loaded exosomes demonstrated 2–10-fold knockdown. Exosome carrying si KRAS showed dose-dependent antiproliferative activity.Author: Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish K. Agrawal, Al-Hassan Kyakulaga, Sarah A...
https://www.sciencedirect.com/science/article/pii/S0168365919307230
In principle, exosomes as siRNA delivery vehicles have multiple advantages over existing drug delivery systems. On one hand, the suitable size of the exosomes permits their …Author: Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108394/
Dec 01, 2016 · The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as viruses, polycationic polymers (e.g. polyethylenimine (PEI)-based particles) and liposomes. Although virus-mediated siRNA delivery leads to long-term gene silencing in the target tissue,...Author: Fahimeh Shahabipour, Maciej Banach, Amirhossein Sahebkar
https://www.deepdyve.com/lp/nature-publishing-group-npg/sirna-delivery-with-exosome-nanoparticles-qie10rqiEq
Apr 08, 2011 · SiRNA delivery with exosome nanoparticles Among these barriers, one of the most important is delivery—the ability to target RNAi agents, such as small interfering (si)RNA, to specific tissues at therapeutic doses.
https://www.nature.com/articles/s41467-019-11718-4
Aug 23, 2019 · Nanoparticles-based drug delivery systems (NDDSs) have shown promising therapeutic efficacy in cancer due to the enhanced permeability and …Author: Tuying Yong, Xiaoqiong Zhang, Nana Bie, Hongbo Zhang, Xuting Zhang, Fuying Li, Abdul Hakeem, Jun Hu,...
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