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https://www.alnylam.com/2019/03/29/pre-clinical-data-delivery-rnai-therapeutics-cns-eye/
Mar 29, 2019 · With regard to ocular delivery, a single intravitreal injection of an siRNA conjugate targeting TTR in rats and NHPs led to potent and durable silencing in the eye. RNAi therapeutics directed to disease-causing, CNS- or ocular-expressed genes represent a potential opportunity to address devastating diseases with enormous burden and unmet need.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Readers are referred to the excellent reviews outlining the physical and immunologic barriers to siRNA delivery to the eye, skin, lung, and brain (26 – 29). Systemic delivery, e.g., intravenous injection, of siRNA poses significantly greater challenges.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
http://www.eurekaselect.com/135751/article
Keywords:Ocular, drug delivery, siRNA, nanoplatforms, polymers, lipid nanoparticles, proteins, dendrimers. Abstract:Drug delivery to the eye is challenging for formulation scientists due to physiological barriers that separate the eye from the rest of the body. A variety of ocular disorders demand the development of optimal drug delivery systems for the administration of drugs and …Author: Manjir Sarma Kataki, Bibhuti Bhusan Kakoti, Melanie Jameson, Aum Solanki, Anjali Hirani, Yashwant Pa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533807/
Controlling gene expression via small interfering RNA (siRNA) has opened the doors to a plethora of therapeutic possibilities, with many currently in the pipelines of drug development for various ocular diseases. Despite the potential of siRNA technologies, barriers to intracellular delivery significantly limit their clinical efficacy.Author: Ajit Thakur, Scott Fitzpatrick, Abeyat Zaman, Kapilan Kugathasan, Ben Muirhead, Gonzalo Hortelano, H...
https://www.researchgate.net/publication/281437790_Nanoplatforms_for_Delivery_of_siRNA_to_the_Eye
Request PDF Nanoplatforms for Delivery of siRNA to the Eye Abstract: Drug delivery to the eye is challenging for formulation scientists due to physiological barriers that separate the eye from ...
https://bmcophthalmol.biomedcentral.com/articles/10.1186/1471-2415-10-25
Oct 01, 2010 · Gene silencing in the retina using RNA interference could open broad possibilities for functional studies of genes in vivo and for therapeutic interventions in eye disorders. Therefore, there is a considerable demand for protocols to deliver siRNA into the vertebrate retina.Author: Andrey Turchinovich, Georg Zoidl, Rolf Dermietzel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723413/
Sep 06, 2019 · Autosomal dominantly inherited genetic disorders such as corneal dystrophies are amenable to allele-specific gene silencing with small interfering RNA (siRNA). siRNA delivered to the cornea by injection, although effective, is not suitable for a frequent long-term treatment regimen, whereas topical delivery of siRNA to the cornea is hampered by the eye surface’s protective …Author: Davide Schiroli, María José Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura C. Mairs, Kathleen A....
https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-6-7
Dec 01, 2012 · Nanocarriers for ocular siRNA delivery. This illustration shows four types of pegylated nanocarriers for ocular siRNA delivery: A) polymer, B) liposome, C) protein, D) dendrimer. The siRNA payload is typically entrapped, encapsulated or covalently bound to …Author: Ajit Thakur, Scott Fitzpatrick, Abeyat Zaman, Kapilan Kugathasan, Ben Muirhead, Gonzalo Hortelano, H...
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