We have collected information about Sirna Delivery To Brain for you. Follow the links to find out details on Sirna Delivery To Brain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
In fact, in the single clinical trial reported for RNAi delivery to brain tumor (which targeted tenancin-C), the siRNA was injected directly into infiltrative (inoperable) regions of brain tumor . Steady progress in tissue-targeting methods has enabled researchers to deliver siRNA to diseased tissues or organs via the systemic route with positive outcomes, including the brain.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo [ 43 ]. siRNA duplexes can be monobiotinylated [ 52 ], which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin technology.Author: William M. Pardridge
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Intravenously injected RVG-targeted exosomes delivered GAPDH siRNA specifically to neurons, microglia, oligodendrocytes in the brain, resulting in a specific gene knockdown.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/17434235
Mar 30, 2007 · Weekly, intravenous RNAi with PILs enables a 90% knockdown of the human epidermal growth factor receptor, which results in a 90% increase in survival time in mice with intra-cranial brain cancer. Similar to the delivery of antisense agents, short interfering RNAi (siRNA) duplexes can be delivered with the combined use of targeting MAb's and avidin-biotin technology.Author: William M. Pardridge
https://3ejrvdou7mi16guil1ho2me1-wpengine.netdna-ssl.com/wp-content/uploads/sites/21/2019/02/InVivoTransfection3.pdf
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in …
Searching for Sirna Delivery To Brain?
You can just click the links above. The data is collected for you.
