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https://www.sciencedirect.com/science/article/pii/S0169409X09001495
Delivery systems that can improve siRNA stability and cancer cell-specificity need to be developed, involving the minimizing of off-target and nonspecific immune stimulatory effects. As the route of administration may differ depending on the nature of the cancer, the delivery systems must be optimized for specific cancers.Author: Yu-Kyoung Oh, Tae Gwan Park
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Herein, we review the design criteria for siRNA delivery systems and potential siRNA drug delivery systems for cancer therapy, including chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others.Author: Cong-fei Xu, Jun Wang
https://www.ncbi.nlm.nih.gov/pubmed/19422869
Aug 10, 2009 · siRNA delivery systems for cancer treatment. ... Although several siRNA candidates for the treatment of ocular and respiratory diseases are undergoing clinical trials, there are challenges inherent in the further development of siRNAs for anti-cancer therapeutics, because systemic administration will be required in most cases. ... and physical ...Author: Yu-Kyoung Oh, Tae Gwan Park
https://www.researchgate.net/publication/24408871_SiRNA_delivery_systems_for_cancer_treatment
Overall, these results indicate that Bmi1 as a regulating gene for cancer stem cell is an effective target for cancer treatment using siRNA and co-delivery of UA and Bmi1 siRNA using folate ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857056/
Oct 17, 2019 · Due to the broad scope of possible EV applications, this review focuses on the use and efficacy of EVs derived from eukaryotic cells as drug delivery systems for cancer treatment. Other approaches involving EV-like particles used as anti-cancer vaccines 13 or …Author: Sierra Walker, Sara Busatto, Anthony Pham, Ming Tian, Annie Suh, Kelsey Carson, Astrid Quintero, Mar...
https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · Finally, we discuss the nano-based delivery of RNAi therapeutics in preclinical development, including the current status and limitations of anti-cancer treatment. With the growing number of RNAi therapeutics entering the clinical phase, various nanocarriers are expected to play important roles in the delivery of RNAi molecules for cancer ...Author: Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang
https://www.nature.com/articles/7700931
Jan 20, 2006 · siRNA-based approaches in cancer therapy. ... herpes simplex virus and non-viral delivery systems (liposomal formulations, mechanical administration) are …Author: G R Devi
https://www.deepdyve.com/lp/elsevier/sirna-delivery-systems-for-cancer-treatment-vEQavc0UEM
Aug 10, 2009 · siRNA delivery systems for cancer treatment siRNA delivery systems for cancer treatment Oh, Yu-Kyoung; Park, Tae Gwan 2009-08-10 00:00:00 With increasing knowledge on the molecular mechanisms of endogenous RNA interference, small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines for treatment of incurable diseases such as cancers.
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Non-viral delivery systems have great potential for safe and effective delivery of siRNA therapeutics to tumor cells. Nanocarriers such as nanoplexes, lipoplexes, nanoparticles, and liposomes have been commonly used for siRNA delivery. This chapter highlights the importance of non-viral delivery systems in vitro and in vivo cancer therapy.Author: Emine Şalva, Ceyda Ekentok, Suna Özbaş Turan, Jülide Akbuğa
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