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https://www.nature.com/articles/s41598-019-53462-1
Nov 14, 2019 · The higher-order architecture observed in biological systems, like viruses, is very effective in nucleic acid transport. The replications of this system …Author: Alicia Gamboa, Selina F. Urfano, Katrina Hernandez, Deborah A. Fraser, Luladey Ayalew, Katarzyna Slo...
http://oncm.org/v03p0048.htm
For each siRNA delivery system, researchers are looking for one that has the ability to circulate within the blood for an effective duration, the ability to reach target tissues, and high chances for the siRNA to be taken up by the cells. Viral Vectors.
https://www.annualreviews.org/doi/10.1146/annurev-chembioeng-061010-114133
The power behind RNA interference (RNAi) therapy lies in its ability to specifically silence target genes of interest. As more biological data have become available, it has become evident that, in addition to mediating RNAi, siRNA molecules have the potential to potently induce the innate immune system.
https://pubs.acs.org/doi/full/10.1021/mp900094j
The most successful story for systemic delivery of siRNA is the self-assembling, cyclodextrin polymer-based nanoparticles developed by Mark Davis and his colleagues. Till now, this is the first targeted delivery system of siRNA which was approved for clinical trial in April 2008.
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=2621&context=etd
RATIONAL DESIGN OF POLYMERIC SIRNA DELIVERY SYSTEMS by NaJung Kim An Abstract Of a thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Biomedical Engineering ... acting siRNA delivery system in biomedical research. vii .
https://www.liebertpub.com/doi/full/10.1089/nat.2017.0695
MIS416 is a microparticulate formulation derived from propionibacterium acnes cell wall skeletons with intrinsic adjuvant activity. Conjugates of MIS416-SS-peptide containing a disulfide linkage facilitate the cytoplasmic delivery and release of peptides in antigen-presenting cells (APCs). We hypothesized that MIS416-siRNA (small interfering RNA) conjugates, containing a disulfide linkage ...
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Therefore, the development of siRNA-based viral and non-viral delivery systems are required to have an enhanced efficacy, improved stability, and minimized non-specific gene silencing such as off-target effects and immune responses. This chapter focuses on recent improvements in the non-viral siRNA delivery systems in cancer therapy.
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29562
Overexpression of CFL1 in gastric cancer and the effects of its silencing by siRNA with a nanoparticle delivery system in the gastric cancer cell line. Seyedeh Saideh Daryabari. Department of Animal Biology, University of Tabriz, Tabriz, Iran. Search for more papers by this author.
https://www.researchgate.net/publication/337250400_Higher_Order_Architecture_of_Designer_Peptides_Forms_Bioinspired_10_nm_siRNA_Delivery_System
In this study, zein nanofibers based siRNA delivery system has been attempted for the first time. Here, the amphiphilic property of zein and the size advantage of nanofibers have been brought ...
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.201900047
Apr 26, 2019 · A promising siRNA delivery system has previously been developed on the base of polyethylenimine (PEI) and the targeting ligand transferrin (Tf) to specifically reach activated T cells in the lung. In the present work, the focus is on optimizing Tf‐PEI polyplexes for gene knockdown in primary activated T cells by improving their endosomal ...
https://www.researchgate.net/publication/274315448_REVIEW_ON_NON-VIRAL_DELIVERY_SYSTEMS_FOR_siRNA
DELIVERY SYSTEM/VECTORS FEATURES FOR IDEAL siRNA FORMULATION Delivery Systems: The delivery system for siRNA has been grouped broadly …
https://www.mirusbio.com/products/transfection/transit-x2-dynamic-delivery-system
Functional Co-transfection of Plasmid DNA and siRNA Using the TransIT-X2® Dynamic Delivery System. TransIT-X2® Dynamic Delivery System was used to transfect plasmid Cy®5 labeled DNA encoding nuclear YFP and Cy®3 labeled siRNA into HeLa cells. Transfection was performed in 6-well plates with Poly-L-Lysine (PLL) coated coverslips using 4 µl ...
https://arrowheadpharma.com/science/
Targeted RNAi Molecule (TRiM TM) Platform. Arrowhead’s Targeted RNAi Molecule, or TRiM TM, platform utilizes ligand-mediated delivery and is designed to enable tissue-specific targeting while being structurally simple.Targeting has been core to Arrowhead’s development philosophy and the TRiM TM platform builds on more than a decade of work on actively targeted drug delivery vehicles.
https://patents.google.com/patent/US9107957B2/en
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell.
https://www.hindawi.com/journals/jnm/2011/742895/
Small interfering RNAs (siRNAs) technology has emerged as a promising potential treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential of siRNA, there are challenges for developing efficient and specific delivery systems for systemic administration. There are extracellular and intracellular barriers for nanoparticle-mediated delivery. First, nanoparticles ...
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