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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Readers are referred to the excellent reviews outlining the physical and immunologic barriers to siRNA delivery to the eye, skin, lung, and brain (26–29). Systemic delivery, e.g., intravenous injection, of siRNA poses significantly greater challenges.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.annualreviews.org/doi/10.1146/annurev-chembioeng-061010-114133
Since its inception more than a decade ago, the field of short interfering RNA (siRNA) therapeutics has demonstrated potential in the treatment of a wide variety of diseases. The power behind RNA interference (RNAi) therapy lies in its ability to specifically silence target genes of interest. As more biological data have become available, it has become evident that, in addition to mediating ...Author: Kathryn A. Whitehead, James E. Dahlman, Robert S. Langer, Daniel G. Anderson
https://www.ncbi.nlm.nih.gov/pubmed/28379201
Apr 05, 2017 · Therefore, careful design of the delivery systems is essential to fully utilize the potential of this therapeutic solution. This review presents a comprehensive update on the challenges of siRNA delivery and the current strategies used to develop nanoparticulate delivery systems. PMCID: PMC5408169 PMID: 28379201. Publication Types: Review ...Author: Katyayani Tatiparti, Samaresh Sau, Sushil Kashaw, Arun Iyer
https://www.researchgate.net/publication/309027511_Biomaterials_in_siRNA_Delivery_A_Comprehensive_Review
Among the above-mentioned siRNA delivery systems, studies on cationic polymers are gaining increasing attention due to their strong capability to condense large …
https://onlinelibrary.wiley.com/doi/full/10.1002/wnan.1543
To date, various aptamer‐mediated siRNA delivery systems have been developed to enhance the RNA interference (RNAi) efficacy of siRNA via targeted delivery. In this review, we summarize recent advances in developing aptamer‐mediated siRNA delivery systems for RNAi therapeutics, mainly aptamer–siRNA chimeras and aptamer‐functionalized ...Author: Padmanaban Sivakumar, Sumin Kim, Han Chang Kang, Min Suk Shim
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · Springer, A. D. & Dowdy, S. F. GalNAc-siRNA conjugates: leading the way for delivery of RNAi therapeutics. Nucleic Acid. Ther. 28 , 109–118 (2018). This paper is a review on GalNAc–siRNA ...Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
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