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https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · Springer, A. D. & Dowdy, S. F. GalNAc-siRNA conjugates: leading the way for delivery of RNAi therapeutics. Nucleic Acid. Ther. 28 , 109–118 (2018). This paper is a review on GalNAc–siRNA ...Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.youtube.com/watch?v=cK-OGB1_ELE
Dec 16, 2011 · RNA interference (RNAi) is an important process, used by many different organisms to regulate the activity of genes. This animation explains how RNAi works and introduces the two main players ...Author: nature video
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542916/
Mar 30, 2017 · The delivery systems must be optimized for specific cancers, as the route of administration may differ depending on the nature of cancer. The current progress in siRNA delivery systems for liver , Breast [142, 143], prostate , and lung [145,146] cancers is discussed (Table (Table1 1).Author: Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.sciencedirect.com/science/article/pii/S1818087614000646
If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless. Viral vectors, which were among the first vehicles to be studied for siRNA delivery, can induce unacceptable levels of toxicity through the activation of immune responses [38] .Author: Cong-fei Xu, Jun Wang
https://www.researchgate.net/publication/258036544_Delivery_materials_for_siRNA_therapeutics
Delivery materials for siRNA therapeutics Article · Literature Review (PDF Available) in Nature Materials 12(11):967-77 · October 2013 with 4,409 Reads How we measure 'reads'
http://naturedocumentaries.org/6018/rna-interference-rnai-nature-reviews-genetics/
Jun 25, 2014 · Welcome to another post of Molecular Nature series highlighting a gene silencing mechanism known as RNA interference.The discovery was made by Craig Mello and Andrew Fire who shared 2006 Nobel Prize in Physiology and Medicine. Please keep in mind that this video is quite advanced in content and assumes the viewers know about basic molecular biological concepts such …
https://www.sciencedirect.com/science/article/pii/S0168365919307230
The nucleus was stained by DAPI overnight following the manufacturer's instruction. Then the culture medium was discarded, rinsed three times with PBS (pH = 7.4) and replaced with 1 mL of fresh high-glucose DMEM containing Cy3 labeled-siRNA delivery systems (i.e., free siRNA, CBSA/siRNA, CBSA/[email protected], CBSA/[email protected]). The ...Author: Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu
https://en.wikipedia.org/wiki/Small_interfering_RNA
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA non-coding RNA molecules, 20-25 base pairs in length, similar to miRNA, and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading mRNA after transcription, preventing ...
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