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https://www.slideshare.net/kashikantyadav/sirna
Jan 17, 2018 · SiRNA 1. Presentation on: siRNA Presented by: Kashikant Yadav M pharm (Pharmacology) 2. Introduction • Also as short interfering RNA or silencing RNA • Is a class of double-stranded RNA molecules • 20-25 base pairs in length • similar to miRNA • operating within the RNA interference (RNAi) pathway by the enzyme Dicer
https://www.slideshare.net/axmedaxundov/sirna-delivery
Sep 05, 2015 · Gene Delivery Slide 79 of 100 December 2013 Tehran University of Medical Sciences School of Pharmacy Conjugate Delivery Systems: Triantennary GalNAc–siRNA In this system the 3ʹ terminus of the siRNA sense strand is attached to three GalNAc molecules by means of a triantennary spacer. Multivalency of the sugar ligand greatly improves cell ...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Still, the exact endosomal release mechanism of many siRNA delivery systems is poorly understood. Additionally, low toxicity is the most important part of siRNA delivery systems. If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless.Author: Cong-fei Xu, Jun Wang
https://www.ncbi.nlm.nih.gov/pubmed/28423924
To overcome these challenges, systemic siRNA therapy warrants the development of clinically suitable, safe, and effective drug delivery systems. Herein, we review the barriers, potential siRNA drug delivery systems, and application of siRNA in clinical trials for cancer therapy.Author: Aishwarya Singh, Piyush Trivedi, Narendra Kumar Jain
https://ashpublications.org/blood/article/113/12/2646/25005/A-novel-in-vivo-siRNA-delivery-system-specifically
Herein, we have shown, for the first time, a novel cell-specific in vivo delivery system for siRNA by modifying liposomal approaches. 12-16 Our novel approach, which we termed siRNA immunoliposomes (siILs), demonstrated a potent and long-lasting cell-specific gene-silencing efficiency and can potentially increase the feasibility of RNAi therapy ...Author: Xiufen Zheng, Xiufen Zheng, Costin Vladau, Xusheng Zhang, Xusheng Zhang, Motohiko Suzuki, Thomas E. ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · There have been several excellent recent reviews on siRNA delivery, with in-depth discussion usually on a specific system (e.g., siRNA conjugates, lipid-based siRNA delivery, polymer nanocarriers, and peptide transduction domains and cell-penetrating peptide) (4–7) or specialized delivery techniques (e.g., hydrodynamic intravascular injection ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can …Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044138
A Novel In Vivo siRNA Delivery System Specifically Targeting Liver Cells for Protection of ConA-Induced Fulminant Hepatitis. Nan Jiang , ¶ * These authors contribute to this work equally.
https://www.scribd.com/presentation/90853030/siRNA-PPT
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