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https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review discusses the biological challenges that siRNA delivery materials aim to overcome, as well as the most clinically advanced classes …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.annualreviews.org/doi/10.1146/annurev-chembioeng-061010-114133
Unless appropriate experimental measures are taken to control for RNA-induced immunostimulation, genetic manipulation can be confused with immune activation. This review attempts to provide an accessible background in siRNA-relevant immunology and to highlight the ways in which siRNA can be engineered to avoid or provoke an innate immune response.Author: Kathryn A. Whitehead, James E. Dahlman, Robert S. Langer, Daniel G. Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542916/
Mar 30, 2017 · The delivery systems must be optimized for specific cancers, as the route of administration may differ depending on the nature of cancer. The current progress in siRNA delivery systems for liver , Breast [142, 143], prostate , and lung [145,146] cancers is discussed (Table (Table1 1).Author: Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, A...
https://www.biologicsblog.com/fda-approves-first-ever-sirna-therapy/
Aug 10, 2018 · Today FDA approved the first-ever “small interfering RNA” (siRNA) product, marking a significant milestone in the story of RNA interference (RNAi) technology and clearing the way for a new type of therapeutic. Alnylam® secured approval and Orphan Drug Designation for its siRNA product Onpattro (patisiran), a therapy for the rare hereditary disease transthyretin-mediated amyloidosis in ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830781/
In this review, the development of dendrimer-based siRNA delivery vectors is summarized, focusing on the vector features (siRNA delivery efficiency, cytotoxicity, etc.) of different types of dendrimers and the related investigations on structure-activity relationship to …Author: Jiangyu Wu, Weizhe Huang, Ziying He
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open overlay panel ... Herein, we review the design criteria for siRNA delivery systems and potential siRNA drug delivery systems for cancer therapy, including chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems ...Author: Cong-fei Xu, Jun Wang
https://www.researchgate.net/publication/51243923_SiRNA_Delivery_challenges_and_role_of_carrier_systems
This review provides an update on the advances in the non-viral delivery approaches for siRNA delivery for skin disorders and use of various delivery approaches for efficient delivery at the ...
https://febs.onlinelibrary.wiley.com/doi/full/10.1111/j.1742-4658.2010.07904.x%4010.1002/%28ISSN%291742-4658%28CAT%29FreeReviewContent%28VI%29Reviews1011
Oct 11, 2010 · In many aspects, siRNA delivery is similar to that of delivering other types of nucleic acids such as plasmid DNA, because they share most extracellular and intracellular barriers. However, several unique challenges in siRNA delivery make achieving efficient …Author: Min Suk Shim, Young Jik Kwon
https://www.researchgate.net/publication/221876257_Silencing_or_Stimulation_siRNA_Delivery_and_the_Immune_System
Silencing or Stimulation? siRNA Delivery and the Immune System Article · Literature Review (PDF Available) in Annual Review of Chemical and Biomolecular Engineering 2(1):77-96 · July 2011 with ...
https://www.onlinelibrary.wiley.com/doi/abs/10.1002/smll.201001389
This review surveys the broad spectrum of nanomaterials and their functional add‐ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery. Citing Literature Volume 7 , …Author: Shawn J. Tan, Pichamon Kiatwuthinon, Young Hoon Roh, Jason S. Kahn, Dan Luo
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