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https://www.ncbi.nlm.nih.gov/pubmed/28379201
Apr 05, 2017 · Therefore, careful design of the delivery systems is essential to fully utilize the potential of this therapeutic solution. This review presents a comprehensive update on the challenges of siRNA delivery and the current strategies used to develop nanoparticulate delivery systems. PMCID: PMC5408169 PMID: 28379201. Publication Types: Review ...Author: Katyayani Tatiparti, Samaresh Sau, Sushil Kashaw, Arun Iyer
https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201200028
Mar 27, 2012 · Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post‐transcriptional gene silencing, so‐called RNA interference.Author: Hee‐Kyung Na, Mi‐Hee Kim, Kihyun Park, Soo‐Ryoon Ryoo, Kyung Eun Lee, Hyesung Jeon, Ryong Ryoo, Chan...
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.nature.com/articles/nrg3978
Aug 18, 2015 · Small interfering RNA (siRNA)-based drugs offer a promising approach to block the synthesis of disease-causing proteins, although their delivery has posed challenges. The authors review …Author: Anders Wittrup, Anders Wittrup, Judy Lieberman
https://www.researchgate.net/publication/309027511_Biomaterials_in_siRNA_Delivery_A_Comprehensive_Review
Biomaterials in siRNA Delivery: A Comprehensive Review Article in Advanced Healthcare Materials 5(21) · October 2016 with 725 Reads How we measure 'reads'
http://www.eurekaselect.com/94942/article
This review focuses on patents describing the siRNA delivery either in naked form or along with a single/multiple delivery vectors. Many inventors have shown promising results for pulmonary utilization of siRNA and more concentration on delivery system may …Author: Nirav I. Khatri, Mohan N. Rathi, Atul A. Kolte, Girish G. Kore, Manisha S. Lalan, Sonia Trehan, Ambi...
https://www.sciencedirect.com/science/article/pii/S0168365919307230
Therefore, the presence of exosome membranes could improve siRNA delivery to the lung PMN and enhance the adhesion of delivery system to the lung. Download : Download high-res image (827KB) Download : Download full-size image; Fig. 6. In vivo distribution of siRNA delivery systems afterAuthor: Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542916/
Mar 30, 2017 · The delivery systems must be optimized for specific cancers, as the route of administration may differ depending on the nature of cancer. The current progress in siRNA delivery systems for liver , Breast [142, 143], prostate , and lung [145,146] cancers is discussed (Table (Table1 1).Author: Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, A...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open overlay panel Cong-fei Xu Jun ... we review the design criteria for siRNA delivery systems and potential siRNA drug delivery systems for cancer therapy, including chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery ...Author: Cong-fei Xu, Jun Wang
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