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https://www.researchgate.net/publication/309027511_Biomaterials_in_siRNA_Delivery_A_Comprehensive_Review
Among the above-mentioned siRNA delivery systems, studies on cationic polymers are gaining increasing attention due to their strong capability to condense large …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The three goals of this review were to provide an overview of (a) the barriers to siRNA delivery, from the perspectives of physicochemical properties of siRNA, pharmacokinetics and biodistribution, and intracellular trafficking; (b) the non-viral siRNA carriers including cell-penetrating peptides, polymers, dendrimers, siRNA bioconjugates, and ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pubmed/28379201
Apr 05, 2017 · Therefore, careful design of the delivery systems is essential to fully utilize the potential of this therapeutic solution. This review presents a comprehensive update on the challenges of siRNA delivery and the current strategies used to develop nanoparticulate delivery systems. PMCID: PMC5408169 PMID: 28379201. Publication Types: Review ...Author: Katyayani Tatiparti, Samaresh Sau, Sushil Kashaw, Arun Iyer
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open ... safe and effective drug delivery systems. Herein, we review the design criteria for siRNA delivery systems and potential siRNA drug delivery systems for cancer therapy, including chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems ...Author: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/nrg3978
Aug 18, 2015 · Small interfering RNA (siRNA)-based drugs offer a promising approach to block the synthesis of disease-causing proteins, although their delivery …Author: Anders Wittrup, Anders Wittrup, Judy Lieberman
https://onlinelibrary.wiley.com/doi/full/10.1002/wnan.1543
To date, various aptamer‐mediated siRNA delivery systems have been developed to enhance the RNA interference (RNAi) efficacy of siRNA via targeted delivery. In this review, we summarize recent advances in developing aptamer‐mediated siRNA delivery systems for RNAi therapeutics, mainly aptamer–siRNA chimeras and aptamer‐functionalized ...Author: Padmanaban Sivakumar, Sumin Kim, Han Chang Kang, Min Suk Shim
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.sciencedirect.com/science/article/pii/S0168365919307230
Therefore, the presence of exosome membranes could improve siRNA delivery to the lung PMN and enhance the adhesion of delivery system to the lung. Download : Download high-res image (827KB) Download : Download full-size image; Fig. 6. In vivo distribution of siRNA delivery systems afterAuthor: Liuwan Zhao, Chunyan Gu, Ye Gan, Lanlan Shao, Hongwei Chen, Hongyan Zhu
https://www.biologicsblog.com/fda-approves-first-ever-sirna-therapy/
Aug 10, 2018 · In order to work, the siRNA must be inside the cell of interest. This means the siRNA must be transported to the tissue in the body where the target cells reside and then it must cross through the cell’s membrane. These requirements are generally referred to as …
https://www.annualreviews.org/doi/10.1146/annurev-chembioeng-061010-114133
Silencing or Stimulation? siRNA Delivery and the Immune System. Annual Review of Chemical and Biomolecular Engineering Vol. 2:77-96 (Volume publication date July 2011) ... This review attempts to provide an accessible background in siRNA-relevant immunology and to highlight the ways in which siRNA can be engineered to avoid or provoke an innate ...Author: Kathryn A. Whitehead, James E. Dahlman, Robert S. Langer, Daniel G. Anderson
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