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https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/performing-rnai-experiments-in-animals.html
More recently, low volume, normal pressure intravenous delivery of a modified siRNA targeting apolipoprotein B in mice resulted in gene silencing in the liver and jejunum. The siRNA was conjugated with cholesterol to provide targeted delivery, and included backbone and sugar modifications to enhance serum stability [6].
https://www.hindawi.com/journals/jdd/2017/4070793/
siRNA stabilized for in vivo applications is filtered and reabsorbed in the renal proximal tubule (PT), reducing mRNA expression transiently. Prior siRNA efforts have successfully prevented upregulation of mRNA in response to injury. We proposed reducing constitutive gene and protein expression of LRP2 (megalin) in order to understand its molecular regulation in mice.Author: Michael T. Eadon, Ying-Hua Cheng, Takashi Hato, Eric A. Benson, Joseph Ipe, Kimberly S. Collins, Tho...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943428/
Aug 22, 2008 · Evaluation of the therapeutic potential of RNAi for HIV infection has been hampered by the challenges of siRNA delivery and lack of suitable animal models. Using a novel delivery method in humanized mice, we show that siRNA treatment can dramatically ...Author: Priti Kumar, Hong Seok Ban, Sang Soo Kim, Haoquan Wu, Todd Pearson, Dale L. Greiner, Amale Laouar, J...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174/
Aug 11, 2014 · We have used α-Syn small interfering RNA (siRNA) to reduce total and aggregated α-Syn levels in mouse brains. To achieve widespread delivery of siRNAs to the brain we have peripherally injected modified exosomes expressing Ravies virus glycoprotein loaded with siRNA. Normal mice were analyzed 3 or 7 days after injection.Author: JM Cooper, PB Wiklander, JZ Nordin, R Al-Shawi, MJ Wood, M Vithlani, AH Schapira, JP Simons, S El-An...
https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)31031-0.pdf
RVG-9dR-complexed siRNA in mice reduced the LPS-induced TNF-α levels in blood as well as in the brain, leading to a significant reduction in neuronal apoptosis. These results demonstrate that RVG-9dR provides a tool for siRNA delivery to macrophages and microglia and that suppression of TNF-α can potentially be used to
https://stm.sciencemag.org/content/4/130/130ra48.full
Apr 18, 2012 · Fig. S11. Administration of F5-P/PLK1-siRNA complexes suppresses Her2 + breast cancer metastasis in nude mice. Fig. S12. F5-P–mediated siRNA delivery does not induce IFN responses in vitro and in vivo. Fig. S13. A cocktail of siRNAs targeting PLK1, CCND1, and AKT delivered by F5-P has enhanced antitumor effects in vitro and in vivo. Table S1.Author: Yan-dan Yao, Tian-meng Sun, Song-yin Huang, Shuang Dou, Ling Lin, Jia-ning Chen, Jian-bin Ruan, Chen...
https://www.nature.com/articles/s41598-019-52142-4
Nov 01, 2019 · Short interfering RNA (siRNA) possesses special ability of silencing specific gene. To increase siRNA stability, transportation and its uptake by tumor cells, effective delivery to the appropriate ...Author: Azmat Ali Khan, Amer M. Alanazi, Mumtaz Jabeen, Arun Chauhan, Mohammad Azam Ansari
https://www.jove.com/video/59201/a-positioning-device-for-placement-mice-during-intranasal-sirna
In conclusion, the use of a positioning device enables an easy IN inoculation of RVG9R-complexed siRNA in mice, resulting in brain-specific siRNA delivery inducing functional silencing of the target gene. Figure 1: Photographic …Author: Irfan Ullah, Irfan Ullah, Kunho Chung, Jagadish Beloor, Sang-Kyung Lee, Priti Kumar
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · In vitro screening of LNPs for siRNA delivery. Before testing the transfection ability of lipidoids, they were first formulated into LNPs containing siRNA and the helper lipids cholesterol, 1,2 ...Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
https://www.thefreelibrary.com/In+Vivo+siRNA+Delivery+and+Rebound+of+Renal+LRP2+in+Mice.-a0584177229
The initial starting dose of 7.5 mcg/gm body weight was selected to match Ambion's recommended starting dose of in vivo siRNA. This dose was also compared to previously published studies of siRNA delivery in mice which were effective at achieving gene knockdown [10-14].
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