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https://www.researchgate.net/publication/269959221_siRNA_delivery_from_basics_to_therapeutic_applications
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https://www.thermofisher.com/uk/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/rnai-as-tool-for-mammalian-gene-analysis-applications-of-sirnas.html
The realization that RNA interference (RNAi) can be used as a general tool for mammalian gene function studies occurred with the seminal Elbashir et al. (1) publication describing the use of small interfering RNAs (siRNAs) in mammalian cells in 2001.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375670/
Jun 25, 2012 · If harnessed effectively, RNAi could result in a potent targeted therapeutic modality with applications ranging from viral diseases to cancer. The major barrier to realizing the full medicinal potential of RNAi is the difficulty of delivering effector molecules, such as small interfering RNAs (siRNAs), in vivo. ... Another siRNA delivery ...Author: Gavrilov K, Saltzman Wm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727154/
From the perspective of therapeutic applications of RNAi, the most important concern is delivery of the siRNAs to the appropriate tissue. ... as it would lower the siRNA dosage and potentially avoid off-target effects from siRNA delivery to irrelevant tissues. The coupling of siRNAs to aptamers or antibody fragments, or the use of nanoparticles ...Author: Daniel H. Kim, John J. Rossi
https://onlinelibrary.wiley.com/doi/book/10.1002/9781118610749
Apr 26, 2013 · Professor Kun Cheng, Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, USA Professor Cheng's research interests include the delivery and therapeutic applications of RNAi for breast cancer, prostate cancer, liver diseases, and type I diabetes.
https://www.sciencedirect.com/science/article/pii/S1319562X12000629
RNA interference is a post transcriptional gene silencing mechanism that is triggered by double-stranded RNA (dsRNA). Various attributes of the 3′ end structure, including overhang length and sequence composition, plays a primary role in determining the position of the Dicer cleavage in both dsRNA and unimolecular, short hairpin RNA (shRNA).Author: Anghesom Ambesajir, Atul Kaushik, Jeevan J. Kaushik, Sham T. Petros
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open overlay panel Cong-fei Xu Jun Wang. Show more. ... synthetic lipids and polymers have been developed to offer alternatives to viral vectors for nucleic acid delivery applications, ... they show great potential and are necessary in cancer therapeutic siRNA delivery ...Author: Cong-fei Xu, Jun Wang
https://www.researchgate.net/publication/41453418_Advances_in_Systemic_siRNA_Delivery
Advances in Systemic siRNA Delivery. ... and advanced applications for the co-delivery of drugs and siRNA by these delivery systems are reviewed. ... siRNA delivery: from basics to therapeutic ...
https://onlinelibrary.wiley.com/doi/pdf/10.1002/9781118610749.fmatter
Advanced Delivery and Therapeutic Applications of RNAi Edited by KUN CHENG School of Pharmacy, University of ... Part 1 Introduction and Basics of RNAi 1 1 Mechanisms and Barriers to RNAi Delivery 3 ... 7.3 Polymeric Multifunctional siRNA Delivery Systems 150 …
https://www.thoughtco.com/what-is-sirna-and-how-is-it-used-375598
Small interfering RNA (siRNA) are small pieces of double-stranded (ds) RNA, usually about 21 nucleotides long, with 3' (pronounced three-prime) overhangs (two nucleotides) at each end that can be used to "interfere" with the translation of proteins by binding to and promoting the degradation of messenger RNA (mRNA) at specific sequences.
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