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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814166/
Small interfering RNAs (siRNA) are a potential new class of medicines that can selectively silence disease-causing genes 1–3.LNPs are the most advanced siRNA delivery system to date, having recently shown therapeutic efficacy in clinical trials 4.Although efforts to define the physicochemical properties of nanoparticles that contribute to efficient cellular delivery are ongoing, the cellular ...Author: Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889191/
Dec 03, 2013 · Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in neuronal processes. In this article, we show a method for using small interfering RNA (siRNA) in lipid nanoparticles (LNPs) to efficiently silence neuronal gene expression in cell culture and in the brain in vivo through intracranial injection.Author: Ravi L Rungta, Hyun B Choi, Paulo Jc Lin, Rebecca Wy Ko, Donovan Ashby, Jay Nair, Muthiah Manoharan,...
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · To investigate our ability to predict in vivo siRNA delivery potency without any biological testing, we custom synthesized a small second-generation library of …Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
https://www.nature.com/articles/nbt.2614
Jun 23, 2013 · Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. Despite efforts to understand the …Author: Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko,...
https://www.conferenceseries.com/rna-interference.php
The nanoparticle delivery category is the largest segment of the overall market and is expected to grow to $33.4 billion by 2018, registering a CAGR of 25%. However, the aptamer delivery category, which was valued at just $218 million in 2013, is expected to jump to nearly $2.2 billion in 2018.
https://www.researchgate.net/profile/Robert_Dorkin/publication/258036544_Delivery_materials_for_siRNA_therapeutics/links/563bc57308ae45b5d2869cce/Delivery-materials-for-siRNA-therapeutics.pdf
Delivery materials for siRNA therapeutics Rosemary Kanasty 1,2 , Joseph Robert Dorkin 2,3 , Arturo Vegas 2,4 and Daniel Anderson 1,2,4,5,6 * RNA interference (RNAi) has broad potential as a ...
https://www.researchgate.net/publication/258036544_Delivery_materials_for_siRNA_therapeutics
Delivery materials for siRNA therapeutics Article · Literature Review (PDF Available) in Nature Materials 12(11):967-77 · October 2013 with 4,409 Reads How we measure 'reads'
http://adsabs.harvard.edu/abs/2013NatMa..12..967K
Abstract RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short interfering RNA (siRNA) to the site of action in the cells of target tissues.
https://www.hindawi.com/journals/bmri/2013/782041/
Important progress in nanotechnology has led to the development of efficient siRNA delivery systems. In this review, the authors discuss recent advances in nanoparticle-mediated siRNA delivery and the application of siRNA in clinical trials for cancer therapy. This review will also offer perspectives on future applications of siRNA therapeutics.Author: Jong-Min Lee, Tae-Jong Yoon, Young-Seok Cho
https://www.mdpi.com/1999-4923/5/3/498/htm
Lipid nanoparticle (LNP) containing ionizable amino lipids is the leading delivery technology for siRNA, with five products in clinical trials and more in the pipeline. Here, we focus on the technological advances behind these potent systems for siRNA-mediated gene silencing. ... New Biotechnol. 2013, 30, 302–307. [Google Scholar]Author: Yuen Yi C. Tam, Sam Chen, Pieter R. Cullis
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