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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814166/
Small interfering RNAs (siRNA) are a potential new class of medicines that can selectively silence disease-causing genes 1–3.LNPs are the most advanced siRNA delivery system to date, having recently shown therapeutic efficacy in clinical trials 4.Although efforts to define the physicochemical properties of nanoparticles that contribute to efficient cellular delivery are ongoing, the cellular ...Author: Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889191/
Dec 03, 2013 · Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in neuronal processes. In this article, we show a method for using small interfering RNA (siRNA) in lipid nanoparticles (LNPs) to efficiently silence neuronal gene expression in cell culture and in the brain in vivo through intracranial injection.Author: Ravi L Rungta, Hyun B Choi, Paulo Jc Lin, Rebecca Wy Ko, Donovan Ashby, Jay Nair, Muthiah Manoharan,...
https://www.sciencedirect.com/journal/journal-of-drug-delivery-science-and-technology/vol/22/issue/1
Pages 5-108 (2012) Download full issue. Previous vol/issue. Next vol/issue. Actions for selected articles. ... select article Chitosan and its derivatives as nanocarriers for siRNA delivery. ... Conference abstract Full text access ...
https://sirnaomics.com/news/sirnaomics-advances-its-novel-sirna/
Dec 19, 2019 · Sirnaomics is a leading biopharmaceutical company in the discovery and development of siRNA therapeutics. The company’s mission is to advance siRNA therapeutics by using its proprietary multi-targeted siRNA design and screening together with nanoparticle-mediated siRNA delivery vehicles.
https://ieeexplore.ieee.org/document/6346773/
Abstract: Transgenic mice with Tie2- green fluorescent protein (GFP) are used as a model to study the kinetic distribution of the Cy5-siRNA delivered by lipid nanoparticles (LNP) into the liver. After the mouse is injected with the LNP, it undergoes a procedure of intra-vital multi-photon microscopy imaging over a period of two hours, during which the process for the nanoparticle to diffuse ...
https://www.businesswire.com/news/home/20120509005593/en/Arrowhead-Presents-Data-DPC-System-Hepatitis-Program
Arrowhead Presents Data on DPC System and Hepatitis B Program at CLINAM 2012. ... for Clinical Medicine Conference in Basel, Switzerland. Dr. ... Effective siRNA Delivery” described the ...
https://www.nature.com/articles/nbt.2614
Jun 23, 2013 · Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. Despite efforts to …Author: Gaurav Sahay, William Querbes, Christopher Alabi, Ahmed Eltoukhy, Sovan Sarkar, Christopher Zurenko,...
https://www.mrna-conference.com/
8th International mRNA Health Conference November 9-10, 2020 / Boston Park Plaza Hotel, USA 8th International mRNA Health Conference The International mRNA Health Conference is the premier meeting destination for industry and academic professionals to explore the rapidly advancing science and business of mRNA medicines, providing participants a platform to network with colleagues, secure ...
https://iopscience.iop.org/article/10.1088/1361-6528/ab313d
Jul 29, 2019 · IOP Conference Series ... The development of polymer-based nanoparticulate delivery systems for siRNA is important for the clinical success of gene therapy. ... Essex S, de Ilarduya C T and Torchilin V P 2012 P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells Nanomedicine 7 ...Author: Waleed M. Hussein, Waleed M. Hussein, Yee S. Cheong, Chang Liu, Genan Liu, Anjuman Ara Begum, Maria ...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
Delivery systems for siRNA drug development in cancer therapy. Author links open overlay panel Cong-fei Xu Jun Wang. Show more. ... If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless. ... (2012), pp. 1046-1059. Google ScholarAuthor: Cong-fei Xu, Jun Wang
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