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https://www.nature.com/articles/nbt.1830
Apr 08, 2011 · By expressing a neuron-targeting protein on the surface of exosomes, filling them with siRNA and injecting them into the bloodstream of mice, they achieve specific gene knockdown in the brain ( Fig. 1a ). The use of exosomes as an siRNA carrier, although still in its early days,...Author: Jasper G van den Boorn, Martin Schlee, Christoph Coch, Gunther Hartmann
https://www.ncbi.nlm.nih.gov/pubmed/21478846
1. Nat Biotechnol. 2011 Apr;29(4):325-6. doi: 10.1038/nbt.1830. SiRNA delivery with exosome nanoparticles. van den Boorn JG, Schlee M, Coch C, Hartmann G.Author: Jasper G van den Boorn, Martin Schlee, Christoph Coch, Gunther Hartmann
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108394/
Dec 01, 2016 · The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as viruses, polycationic polymers (e.g. polyethylenimine (PEI)-based particles) and liposomes. Although virus-mediated siRNA delivery leads to long-term gene silencing in the target tissue,...Author: Fahimeh Shahabipour, Maciej Banach, Amirhossein Sahebkar
https://www.sciencedirect.com/science/article/pii/S0304383519300837
Gene-silencing with targeted siRNAs has great potential as a therapeutic approach for various diseases including cancer. However, intracellular delivery of siRNA is challenging. We used bovine milk exosomes as a novel system for siRNA delivery. First, we demonstrated that exosomes can deliver endogenous RNA payloads into recipient cells.Author: Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish K. Agrawal, Al-Hassan Kyakulaga, Sarah A...
https://www.sciencedirect.com/science/article/abs/pii/S0304383519300837
Milk exosomes represent a viable natural nano-carrier for the delivery of siRNA. • Exosomes were loaded with siRNA using a chemical transfecting reagent, Exo-Fect. • siRNA loaded exosomes demonstrated 2–10-fold knockdown. • Exosome carrying siKRAS showed dose-dependent antiproliferative activity. •Author: Farrukh Aqil, Radha Munagala, Jeyaprakash Jeyabalan, Ashish K. Agrawal, Al-Hassan Kyakulaga, Sarah A...
https://www.researchgate.net/publication/51037796_SiRNA_delivery_with_exosome_nanoparticles
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild ...
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