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https://www.ncbi.nlm.nih.gov/pubmed/32181988
Mar 17, 2020 · Herein, a cancer cell-like gene delivery system is developed using an excellent polymer poly(β-amino ester) (PBAE) to condense small interfering RNA (siRNA) (targeting to Plk1 gene) into nanoparticles (PBAE/siPlk1) as the core, which is further camouflaged with CCM.Author: Lingmin Zhang, Sai Deng, Yanfen Zhang, Qingsheng Peng, Huan Li, Ping Wang, Xiaomei Fu, Xueping Lei, ...
https://www.ncbi.nlm.nih.gov/pubmed/32170657
Mar 13, 2020 · The present article elaborates on various nanocarriers and their promising outcomes at preclinical stage and future implications of nanocarrier-based siRNA vaginal delivery. Graphical abstract Overview on barriers to the delivery of siRNA by vaginal route and nanocarrier envisaged until date for enhancing efficient delivery of siRNA. PMID: 32170657Author: Krishna Baxi, Sujata Sawarkar, Munira Momin, Vainav Patel, Trinette Fernandes
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.nature.com/articles/nbt.1830
Apr 08, 2011 · WIREs Nanomedicine and Nanobiotechnology (2020) Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo Petro ZhupanynAuthor: Jasper G van den Boorn, Martin Schlee, Christoph Coch, Gunther Hartmann
https://www.biorxiv.org/content/10.1101/2020.01.16.907394v1.full.pdf
delivery 5. The first siRNA therapeutic, called Onpattro ®, was recently approved for treatment of hereditary transthyretin-mediated amyloidosis 6,7, twenty years after the discovery of RNA interference 8. Onpattro ® relies on lipid nanoparticle (LNP) technology for siRNA delivery to hepatocytes where
https://www.sciencedirect.com/science/article/pii/S0168365920301759
The transdermal siRNA delivery not only possesses the excellent anti-tumor performance for the treatment of superficial cancers but also has great application potential in many skin genetic diseases that tend to occur over a wide area in the face, head and neck, for which current delivery systems are neither clinically justifiable nor effective ...Author: Mao-Ze Wang, Jie Niu, Hui-Jian Ma, Haseeb Anwar Dad, Hai-Tao Shao, Tie-Jun Yuan, Li-Hua Peng, Li-Hua...
https://www.mdpi.com/1999-4923/12/2/178/pdf
Pharmaceutics 2020, 12, 178 2 of 3 strategies employed to minimize siRNA delivery problems, the targeting strategies to ovarian cancer and the preclinical models available.Author: Gaetano Lamberti, Anna Angela Barba
https://www.astrazeneca.com/media-centre/press-releases/2020/astrazeneca-to-discover-and-develop-sirna-therapeutics-for-cardiovascular-renal-metabolic-and-respiratory-diseases-in-new-collaboration.html
Mar 25, 2020 · Targeted delivery to these other tissues represents a new opportunity to treat Cardiovascular, Renal, Metabolic and Respiratory diseases. Mene Pangalos, EVP BioPharmaceuticals R&D, AstraZeneca said “This collaboration with Silence adds an exciting new modality, siRNA, into our drug discovery toolbox.
https://link.springer.com/article/10.1007/s13346-020-00741-4
Mar 13, 2020 · However, the mucosal barrier and physiological changes in vagina such as pH and variable epithelial layer thickness during menstrual cycle serve as major hurdles for efficient delivery and cellular uptake of siRNA. In order to enhance vaginal delivery of siRNA, nanocarrier systems like lipid-based delivery systems, macromolecular systems ...Author: Krishna Baxi, Sujata Sawarkar, Munira Momin, Vainav Patel, Trinette Fernandes
https://www.biosyn.com/tew/In-vivo-delivery-of-lipophilic-siRNA.aspx
Covalent siRNA cholesterol conjugates are known to increase import into cellular where they induce RNAi resulting in the silencing of endogenous genes in vivo. Wolfram et al. in 2007 reported the preparation of a variety of lipophilic carrier molecules useful for optimized cell delivery. Long-chain fatty acid conjugates are helpful for cell ...
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