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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767078/
Sep 11, 2019 · Hence, siderophore-mediated antibiotic delivery via conjugates offers an exciting approach to turn known Gram-positive antibiotics into Gram-negative antibiotics. Using a mixed catechol and hydroxmate siderophore analogue, mimicking the natural siderophore fimsbactin of Gram-negative A. baumannii , Gosh et al. turned the Gram-positive antibiotic daptomycin into a potent killer in vitro …Author: Kokob H. Negash, James K.S. Norris, James T. Hodgkinson
https://www.sciencedirect.com/science/article/pii/S1074552196901672
Conjugation of drugs to synthetic hydroxamate or catechol siderophore components can facilitate active iron-transport-mediated drug delivery. While resistance to the siderophore—drug conjugates frequently occurs by selection of mutants deficient in the corresponding siderophore-selective outer membrane receptor, the mutants are less able to survive under iron-deficient conditions and in vivo .Author: Arun Ghosh, Manuka Ghosh, Chuan Niu, François Malouin, Ute Moellmann, Marvin J. Miller
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380153/
Jun 20, 2012 · The Fe(III)-siderophore complexes are recognized and active transport through the bacterial cell membrane is intitiated via specific receptors. 4–5 Attachment of antibiotics to siderophores produces potential “Trojan Horse” conjugates that are anticipated to enter pathogenic bacteria via their iron uptake system, thereby circumventing the permeability-mediated drug resistance problem.Author: Cheng Ji, Patricia A. Miller, Marvin J. Miller
https://www.cell.com/cell-chemical-biology/pdf/S1074-5521(96)90167-2.pdf
iron-transport-mediated drug’ delivery. While resistance to the siderophore-drug conjugates frequently occurs by selection of mutants deficient in the correspond- ing siderophore-selective outer membrane receptor, the mutants are less able to survive under iron-deficient conditions and in viva.
https://pubs.acs.org/doi/10.1021/bc00010a013
Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds and Evaluation of Enterobactin–Cargo Conjugate Uptake. Journal of the American Chemical Society 2012, 134 (44) , 18388-18400. DOI: 10.1021/ja3077268.Author: Julia A. McKee, Sushil K. Sharma, Marvin J. Miller
http://pubs.acs.org/doi/abs/10.1021/bc00010a013
Iron Transport-Mediated Drug Delivery: Practical Syntheses and In Vitro Antibacterial Studies of Tris-Catecholate Siderophore–Aminopenicillin Conjugates Reveals Selectively Potent …
https://pubs.acs.org/doi/abs/10.1021/bc00010a013
Iron transport mediated drug delivery systems: synthesis and antibacterial activity of spermidine- and lysine-based siderophore - .beta.-lactam conjugates
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