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https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(18)30315-X/fulltext
Apr 09, 2018 · Siderophore–antibiotic compounds may also encounter bacterial resistance mechanisms, as shown for the monocarbam SMC-3176 for which a rapid adaptive resistance preventing entry via the siderophore-mediated iron uptake systems has been observed in Pseudomonas aeruginosa strains [9 x [9] Kim, A., Kutschke, A., Ehmann, D.E., Patey, S.A., Crandon ...Author: Isabelle J. Schalk, Isabelle J. Schalk
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767078/
Sep 11, 2019 · New strategies for antibiotic drug design and delivery offer a glimmer of hope in a currently limited pipeline of new antibiotics. One strategy involves conjugating iron-chelating microbial siderophores to an antibiotic or antimicrobial agent to enhance uptake and antibacterial potency.Author: Kokob H. Negash, James K.S. Norris, James T. Hodgkinson
https://www.researchgate.net/publication/24005777_Siderophores_as_drug_delivery_agents_application_of_the_Trojan_Horse_strategy
Conjugation of drugs to synthetic hydroxamate or catechol siderophore components can facilitate active iron-transport-mediated drug delivery. While resistance to the siderophore-drug conjugates ...
https://www.ncbi.nlm.nih.gov/pubmed/29129658
Jan 10, 2018 · Comparative study of siderophore biosynthesis pathway in pathogens provides potential targets for antibiotics and host drug delivery as a part of computationally feasible microbial therapy. Iron acquisition using siderophore models is an essential and well established model in all microorganisms and microbial infections a known to cause great ...Author: Kalyani Dhusia, Archana Bajpai, P.W. Ramteke
https://www.sciencedirect.com/science/article/pii/S0223523419307494
The siderophore-antibiotic drug design strategy provides a good opportunity to discover new antibiotic drugs against multi-drug resistant Gram-negative strains. Compared with the parent antibiotics, the antibacterial selectivity of the conjugates can be improved [ 51 , 59 , 63 , 76 ], as each bacterial species produces and uses specific ...Author: Huimin Kong, Weiyan Cheng, Han Wei, Yongliang Yuan, Zhiheng Yang, Xiaojian Zhang
https://www.sciencedirect.com/science/article/pii/S1074552196901672
Research Paper 1011 Iron transport-mediated drug delivery using mixed-ligand siderophore-[3-lactam conjugates Arun Ghosh,1 Manuka Ghosh,1 Chuan Niu,1 Franpois Malouin,2* Ute Moellmann3 and Marvin J Millerl Background: Assimilation of iron is essential for microbial growth.Author: Arun Ghosh, Manuka Ghosh, Chuan Niu, François Malouin, Ute Moellmann, Marvin J. Miller
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00102
Targeted Antibiotic Delivery: Selective Siderophore Conjugation with Daptomycin Confers Potent Activity against Multidrug Resistant Acinetobacter baumannii Both in Vitro and in Vivo Manuka Ghosh,† Patricia A. Miller,†,‡ Ute Möllmann, † William D. Claypool,§ Valerie A. Schroeder,∥
https://www.ijcmas.com/vol-2-12/Syed%20Sajeed%20Ali%20and%20N.N.%20Vidhale.pdf
succinate media. Siderophore and their derivative have large application in agriculture as to increase soil fertility and biocontrol for fungal pathogen. In medicine the most important application is selective drug delivery, a Trojan horse strategy, to defeat drug resistant bacteria. Siderophore also used to …
https://www.cell.com/cell-chemical-biology/pdf/S1074-5521(96)90167-2.pdf
iron-transport-mediated drug’ delivery. While resistance to the siderophore-drug conjugates frequently occurs by selection of mutants deficient in the correspond- ing siderophore-selective outer membrane receptor, the mutants are less able to survive under iron-deficient conditions and in viva.
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