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https://www.researchgate.net/publication/7471417_Role_of_efflux_pumps_and_metabolising_enzymes_in_drug_delivery
In summary, this review emphasises the urgent need to make changes in drug discovery and drug delivery as efflux pumps and metabolising enzymes play an important role …
https://www.tandfonline.com/doi/abs/10.1517/17425247.2.4.683
Aug 11, 2005 · In this review, the role of efflux pumps in drug delivery and the importance of their tissue distribution is discussed in detail. To improve pharmacokinetic parameters of substrates, various strategies that modulate the activity of efflux proteins are also described. Drug metabolising enzymes mainly include the cytochrome P450 family of enzymes.Author: Suresh Katragadda, Balasubrahmanyam Budda, Banmeet S Anand, Ashim K Mitra
https://www.researchgate.net/publication/12069382_Molecular_Basis_of_Ethnic_Differences_in_Drug_Disposition_and_Response
In summary, this review emphasises the urgent need to make changes in drug discovery and drug delivery as efflux pumps and metabolising enzymes play an important role …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573846/
Oct 15, 2012 · Katragadda S, Budda B, Anand BS, Mitra AK. Role of efflux pumps and metabolising enzymes in drug delivery. Expert Opin Drug Deliv. 2005; 2:683–705. Kemper EM, Cleypool C, Boogerd W, Beijnen JH, van Tellingen O. The influence of the P-glycoprotein inhibitor zosuquidar trihydrochloride (LY335979) on the brain penetration of paclitaxel in mice.Author: Mukul Minocha, Varun Khurana, Bin Qin, Dhananjay Pal, Ashim K. Mitra
https://pubs.acs.org/doi/10.1021/jm021012t
Role of efflux pumps and metabolising enzymes in drug delivery. Expert Opinion on Drug Delivery 2005, 2 (4) , 683-705. DOI: 10.1517/17425247.2.4.683. Suresh Katragadda, Balasubrahmanyam Budda, Banmeet S Anand, Ashim K Mitra. Role of efflux pumps and metabolising enzymes in drug delivery.Author: Dietmar Schwab, Holger Fischer, Ali Tabatabaei, Sonia Poli, Jörg Huwyler
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196121/
Among drug metabolizing enzymes and efflux transporters present in the small intestinal mucosa, cytochrome P450 (CYP) enzymes, in particular the CYP3A subfamily, and P-glycoprotein (P-gp), encoded by the multidrug resistance (mdr1a) gene, are of particular interest as they accommodate a very wide spectrum of substrates and they exhibit a high ...Author: Shoji Kawauchi, Tsutomu Nakamura, Hiroyuki Yasui, Chikako Nishikawa, Ikuya Miki, Jun Inoue, Sayo Hor...
https://quizlet.com/gb/409624784/drug-metabolism-and-excretion-flash-cards/
-role of interplay between metabolising enzymes and drug transporters-Drug-drug interactions involving liver transporters. ... (efflux pumps) multidrug resistance in cancer. solute linked carrier (SLC) transporters ... major role of efflux transporters (ABC and MATE) in excretion of metabolites ...
https://www.nps.org.au/australian-prescriber/articles/p-glycoprotein-and-its-role-in-drug-drug-interactions
Efflux transporters such as P-glycoprotein play an important role in drug transport in many organs. In the gut, P-glycoprotein pumps drugs back into the lumen, decreasing their absorption. Drugs which induce P-glycoprotein, such as rifampicin, can reduce the bioavailability of some other drugs.Author: Andrew Finch, Peter Pillans
https://www.nature.com/articles/nrd2468
Mar 01, 2008 · Prodrugs are bioreversible derivatives of drug molecules that must undergo an enzymatic and/or chemical transformation in vivo to release the active parent drug, which can then exert its …Author: Jarkko Rautio, Hanna Kumpulainen, Tycho Heimbach, Reza Oliyai, Dooman Oh, Tomi Järvinen, Jouko Savol...
https://www.sciencedirect.com/science/article/pii/S1773224710500121
This review mainly focuses on the efflux pumps which play an important role in drug absorption and a few strategies to overcome these efflux pumps. Key words Efflux proteins Multi-drug resistance ATP-binding cassette Substrate Transporter Transporter targeted drug delivery Prodrug Bioavailability REFERENCES 1.Author: N. Mandava, R.K. Oberoi, M. Minocha, A.K. Mitra
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