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http://www.nature.com/nature/journal/v464/n7292/full/4641225a.html
Apr 21, 2010 · The complex process by which small RNAs are able to silence genes by targeting complementary messenger RNA molecules for destruction was recognized and named RNA interference (RNAi) in 1998 (ref. 1 ). In 2004, the first RNAi-based …
https://www.researchgate.net/publication/43299824_RNA_interference_Homing_in_on_delivery
RNA interference (RNAi) technology represents a fundamentally new category of treatments for human disease by addressing targets that are traditionally considered undruggable with existing...Author: Monya Baker
https://www.ncbi.nlm.nih.gov/pubmed/20414308
Apr 22, 2010 · RNA interference: Homing in on delivery. Baker M. PMID: 20414308 [PubMed - indexed for MEDLINE] MeSH Terms. ... Drug Carriers/metabolism; Drug Carriers/pharmacokinetics; Drug Delivery Systems/economics; Drug Delivery Systems/methods* Gene Knockdown Techniques/economics; Gene Knockdown Techniques/methods* ... RNA Interference* RNA, Small ...Author: Monya Baker
https://ui.adsabs.harvard.edu/abs/2010Natur.464.1225B/abstract
The scientific community now seems convinced that small RNAs will become therapies, if new tools can help these large molecules to make it safely into cells. Monya Baker reports.Author: Monya Baker
http://adsabs.harvard.edu/abs/2010Natur.464.1225B
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http://fulltext.calis.edu.cn/nature/nature/464/7292/4641225a.pdf
Homing in on delivery The scientific community now seems convinced that small RNAs will become therapies, if new tools can help these large molecules to make it safely into cells.
https://link.springer.com/article/10.1007%2Fs10555-017-9717-6
Dec 14, 2017 · RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic cond Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful systemic delivery.Author: Xiuhui Chen, Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel L...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference is a powerful molecular tool for silencing aberrant gene expression in diseased tissues. Thus, the technique has elicited considerable interest as a method to target human disease. Despite its promise as a novel mode of therapy, the primary difficulty in utilizing this technique has been the delivery of therapeutic quantities of siRNA to the tissue in vivo .Author: Saroj P Mathupala
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Nanoparticle encapsulation of RNA physically protects nucleic acids from degradation and, depending on the specific chemistry, can aid in cellular uptake and endosomal escape. Given their high degree of chemical flexibility, polymers are commonly used materials for nanoparticle-based delivery …Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://en.wikipedia.org/wiki/RNAi
Lentiviral delivery of designed shRNAs and the mechanism of RNA interference in mammalian cells. RNA interference (RNAi) is a biological process in which RNA molecules inhibit gene expression or translation, by neutralizing targeted mRNA molecules.
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