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https://www.ncbi.nlm.nih.gov/pubmed/16952275
Because RNA-interference effectors are macromolecular and typically polyanionic, their efficacy is poor when not accompanied by a delivery vehicle. This review outlines the RNA-interference mechanism and discusses the delivery of RNA-interference effectors, with an emphasis on synthetic polymer-based delivery systems. PMID: 16952275Author: D. Putnam, A. Doody
https://www.cell.com/cell/pdf/S0092-8674(18)30207-1.pdf
d Neuronal AAV delivery of dCasRx splice effectors alleviates tau mis-splicing Authors Silvana Konermann, Peter Lotfy, ... to study and manipulate RNA lag significantly behind their DNA counterparts. Existing RNA interference technologies, which enable cleavage or inhibition of desired transcripts, have signifi- ...
https://www.researchgate.net/publication/285179890_Bacterial_Delivery_of_RNAi_Effectors
Delivery of RNA-based therapeutics, for example RNA interference (RNAi) effectors, to target cells is one of the major obstacles for the development of RNA-based therapies.
http://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,2c7ebfdd101fd750,4c54ef8600d258e0.html
Because RNA-interference effectors are macromolecular and typically polyanionic, their efficacy is poor when not accompanied by a delivery vehicle. This review outlines the RNA-interference mechanism and discusses the delivery of RNA-interference effectors, with an emphasis on synthetic polymer-based delivery systems.
https://bmcbiotechnol.biomedcentral.com/articles/10.1186/s12896-017-0328-7
Feb 09, 2017 · RNAi (RNA interference) is a technology for silencing of target genes via sequence-specific manner. RNAi technology has been used for development of anti-pathogenic crops. In 2007, development of transgenic plants resistant to insect herbivore using RNAi technology was first reported, leading to a burst of efforts aimed at exploitation of RNAi mechanism and control strategy against …Author: Oyunchuluun Ganbaatar, Budao Cao, Yanan Zhang, Duran Bao, Wenhua Bao, Hada Wuriyanghan
https://www.researchgate.net/publication/257348237_Polyethylenimine_and_chitosan_carriers_for_the_delivery_of_RNA_interference_effectors
Polyethylenimine and chitosan carriers for the delivery of RNA interference effectors Article · Literature Review in Expert Opinion on Drug Delivery 10(12) · October 2013 with 42 Reads
https://www.sciencedirect.com/science/article/pii/B9780123942951000056
However, insufficient efficacy of delivery for these therapeutic RNA molecules limited their clinical exploitation. In the 2000s, advances revealed new opportunities for the development of RNA therapeutics, particularly those based on the RNA interference (RNAi) mechanism.Author: Hermann Lage
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