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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418108/
Nanoparticle-based drug delivery still has some limitations, and the barriers and obstacles encountered by nanoparticle-siRNA complexes are schematized in Figure 3 (adapted from Whitehead50). First of all, these vehicles must reach and enter target cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443240/
As nonviral delivery systems, nanoparticles provide versatile platforms for exogenous mRNA expression in vivo. During the delivery process, nanoparticles protect mRNA from RNase degradation, increase their cellular uptake, and facilitate endosome escape, thereby expressing functional proteins in the cytosol (Figure 2). These attributes make it feasible to address technical challenges for in vivo delivery …Author: Bin Li, Xinfu Zhang, Yizhou Dong
https://pubs.acs.org/doi/abs/10.1021/acscombsci.6b00073
RNA nanostructures can be programmed to exhibit defined sizes, shapes and stoichiometries from naturally occurring or de novo designed RNA motifs. These constructs can be used as scaffolds to attach functional moieties, such as ligand binding motifs or gene expression regulators, for nanobiology …Author: Lorena Parlea, Anu Puri, Wojciech K. Kasprzak, Eckart Bindewald, Paul Zakrevsky, Emily Satterwhite, ...
https://www.sciencedirect.com/science/article/pii/S0168365919305796
Design criteria of nanoparticles (NPs) as efficient delivery vectors for miRNAs Despite the progressively increasing knowledge of miRNA ability to mediate biological processes both in vitro and in vivo , critical hurdles related to miRNA delivery should be overcome to promote their clinical application [ 41 , 42 ].Author: Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Tatsuya Osaki, Giulia Adriani, ...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Nanoparticle encapsulation of RNA physically protects nucleic acids from degradation and, depending on the specific chemistry, can aid in cellular uptake and endosomal escape. Given their high degree of chemical flexibility, polymers are commonly used materials for nanoparticle-based delivery …Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.nature.com/articles/gt20175
Jan 17, 2017 · Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs. Nano Lett 2015; 15 : 7300–7306. CASAuthor: S Guan, J Rosenecker
https://www.nature.com/articles/s41565-017-0043-5
Jan 29, 2018 · A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes Srinivas Ramishetti, Inbal Hazan‐Halevy, Ramesh Palakuri, Sushmita Chatterjee , Somu Naidu ...Author: Ranit Kedmi, Nuphar Veiga, Srinivas Ramishetti, Meir Goldsmith, Daniel Rosenblum, Niels Dammes, Inba...
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