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https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.201800065
Aug 21, 2018 · Here, the authors present an overview of RNA‐based therapeutics and recent advances including their delivery systems and clinical applications. In addition, the current challenges of RNA‐based drugs are discussed, followed by perspectives with regard to the development of these promising drug candidates to elicit successful clinical outcomes.Author: Hojeong Shin, Se‐Jin Park, Yeajee Yim, Jungho Kim, Chulwon Choi, Cheolhee Won, Dal‐Hee Min
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · In this review, we discuss the challenges for clinical translation of RNA-based therapeutics, with an emphasis on recent advances in delivery technologies, and present an overview of the applications of RNA-based drugs for modulation of gene/protein expression and genome editing that are currently being investigated both in the laboratory as well as in the clinic.Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641793/
Dec 10, 2015 · Further refinement of mRNA delivery modalities is therefore essential for its development as a therapeutic tool. This review provides an exclusive overview of current state-of-the-art biomaterials and nanotechnology platforms for mRNA delivery, and discusses future prospects to bring these exciting technologies into clinical practice.Author: Mohammad Ariful Islam, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter, Jinjun Shi
https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.201800065
Recently, there have been several reviews focusing on RNA‐based therapeutics. 12, 13 In this review, we present the overview of RNA‐based therapeutics and recent advances including their delivery systems and clinical applications. In addition, the current challenges faced by RNA‐based drugs will be discussed and this will be followed by ...Author: Hojeong Shin, Se‐Jin Park, Yeajee Yim, Jungho Kim, Chulwon Choi, Cheolhee Won, Dal‐Hee Min
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · This review will summarize recent progress in mRNA delivery across several therapeutic modalities. The versatility of mRNA has created several unique opportunities for clinical application, each with unique delivery requirements. ... Advances in the delivery of RNA …Author: Matthew G. Stanton
https://www.technologyreview.com/s/410047/nano-rna-delivery/
Apr 29, 2008 · The researchers report a method for quickly synthesizing more than a thousand different lipid-like molecules and screening them for their ability to deliver short RNA molecules to cells. They’ve...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Readers are referred to the excellent reviews outlining the physical and immunologic barriers to siRNA delivery to the eye, skin, lung, and brain (26–29). Systemic delivery, e.g., intravenous injection, of siRNA poses significantly greater challenges.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.nature.com/articles/gt20175
Jan 17, 2017 · In this review, we summarize recent advances of existing and emerging nonviral vector-based nanotechnologies for IVT-mRNA delivery and briefly …Author: S Guan, J Rosenecker
https://www.nature.com/articles/nrd.2017.243
Jan 12, 2018 · The gene gun was shown to be an efficient RNA delivery and vaccination method ... A detailed review of EMA regulations for RNA vaccines by Hinz and colleagues highlights the different ...Author: Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
https://www.sciencedirect.com/science/article/pii/S0169409X14001033
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies ... A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery. ... This review is part of the Advanced Drug ...Author: Yunching Chen, Dong Yu Gao, Leaf Huang
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