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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
May 05, 2010 · To improve the evaluation of siRNA delivery in vivo, we tailored an approach that quantifies the small RNAs residing in the RISC from the tissues of rodents and monkey. Application of our approach to preclinical animal studies yielded quantitative insights into the in vivo efficiency of siRNA delivery and the mechanism of RNA silencing.Author: Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pom...
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
RNAi In Vivo ... siRNA has rapidly become the most widely used trigger for inducing gene knockdown in cultured mammalian cells. siRNA delivery in vivo is a more challenging task. ... (2004) Protection against lethal influenza virus challenge by RNA interference in vivo. Proc Natl Acad Sci USA 101(23):8682–8686. Bitko V, Musiyenko A ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
In vivo miRNA delivery strategies for cancer therapy. A lot of work has been done in exploiting and evaluating the features of tumor and tumor microenvironment to improve RNA delivery. There are two classes of strategies for miRNA delivery — local and systemic delivery.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.pnas.org/content/115/42/E9944
Oct 16, 2018 · Nanoparticle-mediated delivery of siRNA to hepatocytes has treated disease in humans. However, systemically delivering RNA drugs to nonliver tissues remains an important challenge. To increase the number of nanoparticles that could be studied in vivo, we designed a high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional …Author: Cory D. Sago, Melissa P. Lokugamage, Kalina Paunovska, Daryll A. Vanover, Christopher M. Monaco, Nir...
https://www.biosyn.com/tew/In-vivo-delivery-of-lipophilic-siRNA.aspx
In vivo delivery of lipophilic siRNA RNA interference (RNAi) is a conserved biological process for specific silencing of gene expression. Small interfering RNAs ( siRNAs ) are important tools for the control of gene expression, such as post-transcriptional gene silencing in mammals, including humans.
https://www.researchgate.net/publication/7754449_siRNA_delivery_in_vivo
Although siRNA has great potentials for treating a variety of diseases, the in-vivo delivery of the double-stranded RNA has been challenging [26,27], especially with systemic administration.
https://www.pnas.org/content/102/32/11539
Aug 09, 2005 · Therefore, in vivo gene delivery is an area of considerable interest where genetic materials (e.g., DNA, RNA, and oligonucleotides) could be used to inhibit undesirable gene expression or to synthesize therapeutic proteins (4, 5). Given the potential of gene transfer as a therapeutic tool, the application of nanotechnology in the development of ...Author: Dhruba J. Bharali, Ilona Klejbor, Ewa K. Stachowiak, Purnendu Dutta, Indrajit Roy, Navjot Kaur, Earl...
http://www.nature.com/articles/nbt1101
May 22, 2005 · To evaluate in vivo delivery of siRNA, B16 or gp160-B16, cells (2 × 10 6) were injected subcutaneously into the right flank. The day after the first detection of tumors (day 9), mice were ...Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · The in vivo efficacy of RNA–protein therapy has been demonstrated for a number of diseases. The majority of the studies preferentially target the liver owing to the well-established and efficient methods for RNA delivery into liver tissue.Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.polyplus-transfection.com/products/invivo-jetrna/
in vivo transfection reagents are the most powerful alternative to viral vectors for nucleic acid delivery. They are easy to use, cost-effective and considered as safe and efficient vehicles for RNA delivery. mRNA transfection is rapidly emerging as a promising method for nucleic acid-based therapy and offers an attractive substitute to plasmid DNA. Non-viral mRNA delivery methods have already ...
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