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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226903/
Dec 06, 2011 · Recombinant amphiphilic elastin-mimetic protein micelles demonstrate the capacity to solubilization, encapsulation, and release hydrophobic drugs. Dipyridamole, a lipophilic compound with anti-inflammatory activity, can be solubilized at pH 7.4 …Author: Wookhyun Kim, Jiantao Xiao, Elliot L. Chaikof
https://pubs.acs.org/doi/abs/10.1021/la202864x
Oct 05, 2011 · Amphiphilic block polypeptides can self-assemble into a range of nanostructures in solution, including micelles and vesicles. Our group has recently described the capacity of recombinant amphiphilic diblock copolypeptides to form highly stable micelles. In this report, we demonstrate the utility of protein nanoparticles to serve as a vehicle for controlled drug delivery. Drug-loaded micelles ...Author: Wookhyun Kim, Jiantao Xiao, Elliot L. Chaikof
https://www.researchgate.net/publication/51698275_Recombinant_Amphiphilic_Protein_Micelles_for_Drug_Delivery
Request PDF Recombinant Amphiphilic Protein Micelles for Drug Delivery Amphiphilic block polypeptides can self-assemble into a range of nanostructures in solution, including micelles and vesicles.
https://pubs.acs.org/doi/pdf/10.1021/la202864x
Amphiphilic block polypeptides can self-assemble into a range of nanostructures in solution, including micelles and vesicles. Our group has recently described the capacity of recombinant amphiphilic diblock copolypeptides to form highly stable micelles.
https://www.chaikoflab.org/wp-content/uploads/2012/07/46.pdf
Our group has recently described the capacity of recombinant amphiphilic diblock copolypeptides to form highly stable micelles. In this report, we demonstrate the utility of protein nanoparticles to serve as a vehicle for controlled drug delivery. Drug-loaded micelles were produced by encapsulating dipyridamole as a model hydro-
https://www.sciencedirect.com/science/article/pii/S1742706112001584
This study reports on the use of a 50 nm recombinant protein nanoparticle with a multivalent surface as a vehicle for functionalization with a model imaging agent. Multiple fluorescent probes were covalently conjugated to surface amines of crosslinked amphiphilic elastin-mimetic protein micelles using N-hydroxysuccinimide ester chemistry. In ...Author: Wookhyun Kim, Colin Brady, Elliot L. Chaikof
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404820/
In this study, we report use of a 50 nm recombinant protein nanoparticle with a multivalent surface as a vehicle for functionalization with a model imaging agent. Multiple fluorescent probes were covalently conjugated to surface amines of crosslinked amphiphilic elastin-mimetic protein micelles using N- hydroxysuccinimide ester chemistry.Author: Wookhyun Kim, Colin Brady, Elliot L. Chaikof
https://www.researchgate.net/publication/224037871_Amphiphilic_Protein_Micelles_for_Targeted_In_Vivo_Imaging
Amphiphilic Protein Micelles for Targeted In Vivo Imaging ... capacity of recombinant amphiphilic diblock copolypeptides to form highly stable micelles. ... a vehicle for controlled drug delivery ...
https://www.sigmaaldrich.com/technical-documents/articles/materials-science/poly-amino-acid-block-copolymers.html
Poly(amino acid) Block Copolymers: Concepts for Drug Delivery Systems. Amino acids have diverse chemical properties and can be subdivided according to the nature of their side chains, including those that are aliphatic, aromatic, sulfur-containing, and those that contain ionizable groups.
https://www.hindawi.com/journals/jdd/2013/340315/
Oral administration is the most commonly used and readily accepted form of drug delivery; however, it is find that many drugs are difficult to attain enough bioavailability when administered via this route. Polymeric micelles (PMs) can overcome some limitations of the oral delivery acting as carriers able to enhance drug absorption, by providing (1) protection of the loaded drug from the harsh ...Author: Wei Xu, Peixue Ling, Tianmin Zhang
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